NCT01737073

Brief Summary

This study will enroll Veterans with chronic pain who have been receiving opioid medications (like methadone, percocet, oxycontin) on a regular basis for at least 3 months to treat their pain. The purpose of this study is to understand if two automated interventions that are delivered by phone can improve the safe and effective use of opioid medications and the physical functioning of Veterans with chronic pain who take opioid medications. One intervention, opioid monitoring, will include monthly automated calls to the enrolled Veteran to ask questions about their use of the opioid medications, pain relief, side effects, effect of pain on physical activity and mood and satisfaction with pain care. The other intervention, skills training, includes learning pain management skills using automated calls and a self-help book with weekly feedback calls from a nurse. Veterans who are enrolled in this study will be randomly assigned (by chance, like a flip of a coin) to receive either opioid monitoring only, self-management only, self-management plus opioid monitoring or a weekly automated phone call with wellness tips. Everyone enrolled in the study will complete questionnaires about their pain and other pain-related information at the beginning of the trial, after the interventions are completed 12 weeks later, and 3 and 6 months after treatment ends.

Trial Health

30
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Timeline
Completed

Started Apr 2017

Geographic Reach
1 country

2 active sites

Status
withdrawn

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

November 26, 2012

Completed
3 days until next milestone

First Posted

Study publicly available on registry

November 29, 2012

Completed
4.3 years until next milestone

Study Start

First participant enrolled

April 1, 2017

Completed
Same day until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2017

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2017

Completed
Last Updated

March 7, 2019

Status Verified

March 1, 2019

Enrollment Period

Same day

First QC Date

November 26, 2012

Last Update Submit

March 5, 2019

Conditions

Keywords

chronic painopioidcognitive behavior therapy

Outcome Measures

Primary Outcomes (1)

  • Brief Pain Inventory

    Post-treatment (12 weeks post baseline)

Secondary Outcomes (1)

  • Concordance with opioid treatment practice guidelines

    Post-treatment

Study Arms (4)

IVR self management

EXPERIMENTAL

cognitive behavioral based self management training for chronic pain delivered by interactive voice response (IVR)

Behavioral: IVR self-management

Opioid monitoring

EXPERIMENTAL

monthly interactive voice response (IVR) monitoring of prescription opioid use with feedback to the prescribing physician

Behavioral: Opioid monitoring

IVR self management plus opioid monitoring

EXPERIMENTAL

Cognitive behavioral based self management training for chronic pain delivered by IVR plus monthly IVR monitoring of prescription opioid use with feedback to the prescribing physician

Behavioral: IVR self-managementBehavioral: Opioid monitoring

Enhanced usual care

OTHER

Weekly automated wellness tips via IVR

Other: Enhanced usual care

Interventions

A course of self-management training that includes 12 education and self-management skill modules presented over 12 consecutive weeks. Participants will be asked to practice each skill daily and report via IVR on their completion of the daily skill practice. They will receive a 10 minute call each week from a nurse care manager to discuss their weekly progress.

IVR self managementIVR self management plus opioid monitoring

Monthly automated monitoring of prescription opioid use including pain relief, physical activity, pain-related interference, mood, adverse effects, adherence and satisfaction with treatment.

IVR self management plus opioid monitoringOpioid monitoring

Weekly automated wellness tip and usual clinical care

Enhanced usual care

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • presence of at least moderate musculoskeletal diagnosis pain (i.e., pain scores of 4 as measured by the Numeric Rating Scale) for a period of 3 months. Musculoskeletal diagnosis is a cluster of disorders including:
  • low back and spine conditions
  • osteoarthritis
  • nerve compression
  • other inflammatory and degenerative disorders
  • receipt of chronic opioid therapy \[90 continuous days out of any 104 day period in the prior 12 month\]
  • ability to participate safely in the walking portion of the intervention as evidenced by patient-reported ability to walk at one block
  • availability of a land line or cellular telephone

You may not qualify if:

  • active psychosis or suicidality that could impair participation, identified using validated measures in the baseline screener
  • life threatening or acute medical condition that could impair participation
  • dementia defined by a score of 20 or greater on the St. Louis University Mental Status in the baseline screener
  • any sensory deficits that would impair participation (e.g., hearing loss to a degree that telephone usage is not possible)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Richard L. Roudebush VA Medical Center, Indianapolis, IN

Indianapolis, Indiana, 46202-2884, United States

Location

VA Ann Arbor Healthcare System, Ann Arbor, MI

Ann Arbor, Michigan, 48105, United States

Location

MeSH Terms

Conditions

Chronic Pain

Condition Hierarchy (Ancestors)

PainNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

  • Alicia A. Heapy, PhD

    VA Connecticut Healthcare System West Haven Campus, West Haven, CT

    PRINCIPAL INVESTIGATOR
0

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
FACTORIAL
Sponsor Type
FED
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 26, 2012

First Posted

November 29, 2012

Study Start

April 1, 2017

Primary Completion

April 1, 2017

Study Completion

April 1, 2017

Last Updated

March 7, 2019

Record last verified: 2019-03

Data Sharing

IPD Sharing
Will not share

Locations