Dysfunction of Nutritive Blood Flow as a Determinant of Anabolic Resistance in Older People

NCT01734616 | Completed

• 1 other identifier: F/3/2009
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

With age, muscles tend to waste at 0.5-1% per year, so that an 80 year old may have only 70% of the muscle possessed at 50. Muscle loss makes it harder to carry out tasks that require strength, keep the body balanced and continue activity for a prolonged period, which together may contribute to a loss of independence and an increased risk of falls. The cause of some of this muscle loss with ageing appears to be a reduction in muscle building in response to food. The known decreased limb blood flow in ageing muscle may go some way to explain this as there may be less nutrient delivery to the muscles. The investigators want to test if the known decrease in limb blood flow with age is matched with a decrease in the proportion of blood being delivered directly to the muscles, rather than fat and connective tissue. If so the investigators expect to see an improvement in the ability of muscles to maintain themselves via better capture of amino acids into protein. The investigators also want to test if 20 weeks resistance exercise training or drinking a cocktail of mixture of high flavanol cocoa (which can increase blood flow) and vitamin C can improve limb blood flow to older muscles and help reduce muscle wasting.

Conditions

Regional Blood Flow

Keywords

Microvascular; Muscle; Nutrition; Exercise; Ageing

Outcome Measures

Primary Outcomes (1)

• Microvascular blood volume in response to feeding

  The final study participant was completed and all microvascular blood volume data analysed by August 2012. This outcome measure is applicable to all arms of this study and refers to responsiveness to a 2 hour feed protocol.

  September 2009 - August 2012

Secondary Outcomes (1)

• Muscle protein metabolism in response to feeding

  January - October 2012

Other Outcomes (1)

• Molecular pathways regulating muscle microvascular blood volume

  August 2012 - August 2013

Study Arms (5)

Young

NO INTERVENTION

Young subjects to be controlled to older individuals with interventions

Old

NO INTERVENTION

Older individuals to compare to young and other older intervention groups

Old Exercise

EXPERIMENTAL

Older individuals studied after an intervention of 20 weeks fully-supervised resistance exercise training

Behavioral: Old Exercise

Old Acute Cocoa

EXPERIMENTAL

Older individuals studied with the addition of cocoa flavanols during their acute study

Dietary Supplement: Old Acute Cocoa

Old 7 Day Cocoa

EXPERIMENTAL

Older individuals studied after 7 day supplementation of cocoa flavanols

Dietary Supplement: Old 7 Day Cocoa

Interventions

Old Exercise BEHAVIORAL

Old Exercise

Old Acute Cocoa DIETARY_SUPPLEMENT

Old Acute Cocoa

Old 7 Day Cocoa DIETARY_SUPPLEMENT

Old 7 Day Cocoa

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy volunteers aged 18-28 or 65-75

You may not qualify if:

• Overt muscle wasting i.e. muscle mass is more than 1 standard deviation below normal muscle or FFM for age
• A BMI \< 24 or \> 28 kg•m2.
• Active cardiovascular disease: uncontrolled hypertension (BP \> 160/100), angina, heart failure (class III/IV), arrhythmia, right to left cardiac shunt or recent cardiac event
• Individuals taking beta-adrenergic blocking agents.
• Cerebrovascular disease: previous stroke, aneurysm (large vessel or intracranial).
• Respiratory disease including pulmonary hypertension, COPD, asthma or an FEV1 less than 1.5 l.
• Metabolic disease: hyper and hypo parathyroidism, untreated hyper and hypothyroidism, Cushing's disease, types 1 or 2 diabetes.
• Active inflammatory bowel disease, or renal disease,
• Malignancy
• Recent steroid treatment (within 6 mo), or hormone replacement therapy.
• Clotting dysfunction
• Musculoskeletal or neurological disorders.
• Family history of early (\<55y) death from cardiovascular disease
• Known sensitivity to Definity or methacholine

Sponsors & Collaborators

• University of Nottingham: lead
• The Dunhill Medical Trust: collaborator

Study Sites (1)

Clinical Physiology Laboratory, Graduate Entry Medical School, University of Nottingham, Royal Derby Hospital

Derby, Derbyshire, DE22 3DT, United Kingdom

Location

Related Publications (1)

• Phillips B, Williams J, Atherton P, Smith K, Hildebrandt W, Rankin D, Greenhaff P, Macdonald I, Rennie MJ. Resistance exercise training improves age-related declines in leg vascular conductance and rejuvenates acute leg blood flow responses to feeding and exercise. J Appl Physiol (1985). 2012 Feb;112(3):347-53. doi: 10.1152/japplphysiol.01031.2011. Epub 2011 Oct 13.

  PMID: 21998269 BACKGROUND

MeSH Terms

Conditions

Motor Activity

Interventions

Chocolate

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Food; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages

Study Officials

• John P Williams, PhD, MD

  University of Nottingham

  PRINCIPAL INVESTIGATOR

• Bethan E Phillips, PhD

  University of Nottingham

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 21, 2012
• First Posted: November 27, 2012
• Study Start: September 1, 2009
• Primary Completion: August 1, 2012
• Study Completion: August 1, 2012
• Last Updated: November 28, 2012

Record last verified: 2012-11

Locations

GB (1)