NCT01728272

Brief Summary

Influence of perfusion, miniperfusion and off pump coronary artery bypass grafting to the absorbtion of metoprolol postoperatively, hypothesis in that miniperfusion and off pump surgery does not decrease absorbtion of the metoprolol compared to conventional pefusion.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
45

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Nov 2012

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2012

Completed
12 days until next milestone

First Submitted

Initial submission to the registry

November 13, 2012

Completed
6 days until next milestone

First Posted

Study publicly available on registry

November 19, 2012

Completed
3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2015

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2015

Completed
Last Updated

August 20, 2015

Status Verified

August 1, 2015

Enrollment Period

3.1 years

First QC Date

November 13, 2012

Last Update Submit

August 19, 2015

Conditions

Drug Absorption

Keywords

metoprolol, atrial fibrillation

Outcome Measures

Primary Outcomes (1)

  • absorbtion of the metoprolol

    absorbtion of the metoprolol, blood samples are taken centrifuged, frozed and analyzed

    one year

Secondary Outcomes (1)

  • atrial fibrillation

    one year

Other Outcomes (1)

  • recovery from rocedure

    one year

Study Arms (1)

blood concentration of metoprolol

EXPERIMENTAL

how does off-pump miniperfusion and perfusion CABG influence the absorption of metoprolol after CABG

Drug: blood concentration of metoprolol

Interventions

blood concentration of metoprololDRUG

measure blood concentration of metoprolol

blood concentration of metoprolol

Eligibility Criteria

Age18 Years - 75 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Kuopio University Hospital

Kuopio, Kuopio, 70100, Finland

RECRUITING

MeSH Terms

Conditions

Atrial Fibrillation

Condition Hierarchy (Ancestors)

Arrhythmias, CardiacHeart DiseasesCardiovascular DiseasesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
INVESTIGATOR
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 13, 2012

First Posted

November 19, 2012

Study Start

November 1, 2012

Primary Completion

December 1, 2015

Study Completion

December 1, 2015

Last Updated

August 20, 2015

Record last verified: 2015-08

Locations

FI(1)