The Austrian LEAD (Lung hEart sociAl boDy) Study

NCT01727518 | Active Not Recruiting Results

• 1 other identifier: LEAD1
• Study Type: observational
• Target: 14,966
• Locations: 1 country
• Sites: 1

Brief Summary

The LEAD study is the first longitudinal cohort investigating respiratory, cardiac, and metabolic health in a reference population of Austria.

Conditions

Respiration Disorders; Body Composition, Beneficial; Metabolic Health

Keywords

natural history; lung function; general population; metabolic health

Outcome Measures

Primary Outcomes (1)

• Abnormal Lung Function in the General Population

  Prebronchodilation (pre-BD) and post-BD forced spirometry measurements were determined according to international recommendations (ERS Global Lung Function Initiative). Abnromal lung function determined as forced expiratory volume in 1 second (FEV1) \< Lower Limit of Normal (LLN) or forced vital capacity (FVC) \< LLN or FEV1/FVC \< LLN.

  4 years

Study Arms (1)

Reference Population

No Intervention

Other: As the LEAD study is an observational cohort study, there is no intervention to report.

Interventions

As the LEAD study is an observational cohort study, there is no intervention to report. OTHER

As the LEAD study is an observational cohort study, there is no intervention to report.

Reference Population

Eligibility Criteria

• Age: 6 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Community based cohort

You may qualify if:

• Male and Female,
• Age 6 - 80 years,
• Invitation by study invitation letter

You may not qualify if:

• Insufficient language skills
• pregnancy

Sponsors & Collaborators

• Ludwig Boltzmann Institute for Lung Health: lead

Study Sites (1)

The LEAD Study Center

Vienna, 1140, Austria

Location

Related Publications (4)

• Azizzadeh M, Karimi A, Danninger K, Breyer MK, Breyer-Kohansal R, Konig A, Kaufmann CC, Boutouyrie P, Bruno RM, Mayer CC, Jager B, Hartl S, Burghuber OC, Weber T. Prevalence and determinants of vascular aging in Austria - a holistic view: the LEAD study. J Hypertens. 2025 Dec 30. doi: 10.1097/HJH.0000000000004227. Online ahead of print.

  PMID: 41537373 DERIVED

• Dal Grande A, Van Herck M, Breyer-Kohansal R, Mraz T, Karimi A, Azizzadeh M, Hartl S, Burghuber OC, Wouters EFM, Kautzky-Willer A, Schiffers C, Breyer MK. Incidence of Prediabetes and Diabetes in a European Longitudinal General Population Cohort and Its Associated Factors-Results From the Austrian LEAD Study. J Diabetes Res. 2025 Apr 22;2025:5540276. doi: 10.1155/jdr/5540276. eCollection 2025.

  PMID: 40309217 DERIVED

• Kolli F, Breyer MK, Hartl S, Burghuber O, Wouters EFM, Sigsgaard T, Pohl W, Kohlbock G, Breyer-Kohansal R. Aero-Allergen Sensitization in the General Population: Longitudinal Analyses of the LEAD (Lung Heart Social Body) Study. J Asthma Allergy. 2022 Apr 11;15:461-473. doi: 10.2147/JAA.S349614. eCollection 2022.

  PMID: 35431559 DERIVED

• Breyer-Kohansal R, Hartl S, Burghuber OC, Urban M, Schrott A, Agusti A, Sigsgaard T, Vogelmeier C, Wouters E, Studnicka M, Breyer MK. The LEAD (Lung, Heart, Social, Body) Study: Objectives, Methodology, and External Validity of the Population-Based Cohort Study. J Epidemiol. 2019 Aug 5;29(8):315-324. doi: 10.2188/jea.JE20180039. Epub 2018 Oct 20.

  PMID: 30344197 DERIVED

Related Links

• Homepage of the Austrian LEAD Study for participants and researchers
• Link to the Study profile; published in 2019
• Homepage of Ludwig Bultzmann Institute for lung health

Biospecimen

Retention: SAMPLES WITH DNA

Samples of urine and blood

MeSH Terms

Conditions

Respiration Disorders; Glucocorticoid Receptor Deficiency

Condition Hierarchy (Ancestors)

Respiratory Tract Diseases

Results Point of Contact

• Title: Dr Robab Breyer-Kohansal
• Organization: Ludwig Boltzmann Institute for Lung Health

Robab.Breyer-Kohansal@lunghealth.lbg.ac.at

+436505398439

Study Officials

• Robab Breyer-Kohansal, Prof. Dr.

  Ludwig Boltzmann Institute for Lung Health, Vienna, Austria

  PRINCIPAL INVESTIGATOR

• Marie-Kathrin Breyer, Prof. Dr

  Ludwig Boltzmann Institute for Lung Health, Vienna, Austria

  STUDY DIRECTOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 4, 2012
• First Posted: November 16, 2012
• Study Start: October 1, 2011
• Primary Completion: October 1, 2016
• Study Completion (Estimated): October 1, 2028
• Last Updated: December 17, 2024
• Results First Posted: November 21, 2024

Record last verified: 2024-11

Locations

AU (1)