Filling Pressures of the Left Ventricle in Patients With Significant Aortic Stenosis

NCT01727310 | Completed

• 1 other identifier: I10013
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 2

Brief Summary

Left valvular heart disease has become one of the most common heart disease in Western countries. This disease evolve over many years and are characterized by a long phase where the patient is "asymptomatic". it is characterized by discomfort LV filling may worsen and lead typically to a pressure increase of LV pressure and the left atrium (LA) (1). The onset of symptoms is unpredictable and may occur at the stage of diastolic or systolic dysfunction. Ventricular dysfunction may be insidious, the goal is to detect early dysfunction, knowing that it is often very difficult to know if the patient is actually symptomatic. The onset of symptoms sign an intolerance to the increase in LV filling pressures and LA , causing pulmonary hypertension . Therefore, the study of the level of LV and LA filling pressures , if possible by a noninvasive method, would identify patients apparently asymptomatic even though their condition is advanced. Pressures filling pressures can be explored by two methods:

• cardiac catheterization, which is a direct and invasive measurement method
• echocardiography, which is an indirect measurement method which has the advantage of being non-invasive The goal of this research is to compare the two methods.

Conditions

Valvular Disease

Outcome Measures

Primary Outcomes (1)

• quality of echocardiography

  Evaluate the diagnostic quality of echocardiography to measure the volume of the LA indexed to body surface area compared to cardiac catheterization

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients of both gender hospitalized for a coarctation review, and has received or will be receiving during their stay a complete echocardiography and coronary angiography, and left and right catheterization .

You may qualify if:

• Older than 18 years;
• Patients hospitalized for a coarctation review, and has received or will be receiving during their stay a complete echocardiography and coronary angiography, and left and right catheterization

You may not qualify if:

• Pregnant women
• Patients with a history of valve replacement surgery,
• Patients with other valvular\> grade 2 associated with the coarctation
• Patients known to have ischemic heart disease or in whom angiography showed significant coronary artery disease;
• Patients with chronic or paroxysmal atrial fibrillation
• Patients with a permanently pacemaker

Sponsors & Collaborators

• University Hospital, Limoges: lead

Study Sites (2)

Departement de Cardiologie

Limoges, 87042, France

Location

Departement de Cardiologie

Montpellier, 34295, France

Location

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 12, 2012
• First Posted: November 15, 2012
• Study Start: November 1, 2012
• Primary Completion: May 1, 2014
• Study Completion: May 1, 2014
• Last Updated: May 28, 2014

Record last verified: 2014-05

Locations

FR (2)