Differences in Cognitive Performance and Brain Activity Between Patients With PTSD and OCD

NCT01723033 | Unknown DMC

• 1 other identifier: BHMC-5200
• Study Type: observational
• Target: 30
• Locations: 0 countries
• Sites: N/A

Brief Summary

Comparison of the neurophysiological response of OCD and PTSD patients (both considered anxiety syndromes) in error processing. The patients will perform three computerized tasks while a net of electrodes (for EEG measurement) will be placed on their head. This data will then be compared to a previously collected healthy control sample.

Conditions

PTSD; OCD

Keywords

PTSD; OCD

Outcome Measures

Primary Outcomes (1)

• Yale Brown Obsessive Compulsive Scale (Y-BOCS)

Secondary Outcomes (1)

• Montgomery Asberg Depression Rating Scale (MADRAS)

Other Outcomes (1)

• Clinician rating scale for assessing current and lifetime PTSD (CAPS)

Study Arms (2)

EEG acquisition

15 PTSD patients and 15 OCD patients who will, while wearing a net of electrodes for EEG acquisition on their heads, perform three error detection tasks.

Control

Previously collected healthy student's data

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients will be recruited from the outpatient clinic of the Beersheva Mental Health Center. 15 OCT and 15 PTSD patients

You may qualify if:

• Diagnosis of PTSD or OCD by DSM-IV criteria;
• For OCD subjects a Y-BOCS score larger than 16 composted form both obsession and compulsion patient's responses;
• For PTSD population a CAPS score larger than 40.
• Either no medicated patients or a combination of anti-anxiety, anti-depressant and tranquilizers.
• Patients with minimum depression symptoms (MDRAS \< 18)

You may not qualify if:

• A medical history of other major psychiatric disorder.
• A known ailment of the central nervous system.
• No history of loss of consciousness.
• No history of head injury or abnormal head trauma upon routine imaging.
• No anti-psychotic or anti-epileptic and tricyclic drugs

Sponsors & Collaborators

• Beersheva Mental Health Center: lead

MeSH Terms

Conditions

Stress Disorders, Post-Traumatic

Condition Hierarchy (Ancestors)

Stress Disorders, Traumatic; Trauma and Stressor Related Disorders; Mental Disorders

Study Officials

• Doron Todder, MD

  Beersheva Mental Health Center and Ben Gurion University of the Negev

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Doron Tudor, MD

CONTACT

972-8-6401401; doron.todder@pbsh.health.gov.il

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr.

Study Record Dates

• First Submitted: November 5, 2012
• First Posted: November 7, 2012
• Study Start: December 1, 2012
• Primary Completion: December 1, 2013
• Last Updated: November 8, 2012

Record last verified: 2012-11