Assessment of the V600E Mutation in the B-RAF Gene in Chronic Lymphoproliferative Disease
B-RAF V600E
1 other identifier
observational
20
0 countries
N/A
Brief Summary
The presence of a specific mutation in the gene known as B-RAF has been found in patients who have Hairy Cell Leukemia. In this study this specific mutation known as V600E will be ascertained in peripheral blood samples of patients who have this disease and in a group of patients who have a similar chronic lymphoproliferative conditions such as splenic marginal lymphoma. The finding of this specific mutation will help to verify or exclude the diagnosis of Hairy Cell Leukemia and determine whether patients are in remission.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Nov 2012
Shorter than P25 for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 31, 2012
CompletedStudy Start
First participant enrolled
November 1, 2012
CompletedFirst Posted
Study publicly available on registry
November 2, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2013
CompletedAugust 11, 2017
August 1, 2017
4 months
October 31, 2012
August 10, 2017
Conditions
Outcome Measures
Primary Outcomes (1)
detection of the B-RAF V600E mutation
2 weeks
Eligibility Criteria
Patients who are followed up in the Haematology Department in the Emek Medical Center for Hairy Cell Leukemia or chronic lymphoproliferative disease such as Splenic Marginal Zone Lymphoma. Patients who are examined and suspected to have Hairy Cell Leukemia.
You may qualify if:
- Patients over the age of 18 years -
You may not qualify if:
- Patients less than 18 years in age or mentally defectives.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Biospecimen
perpheral blood
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- OTHER
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
October 31, 2012
First Posted
November 2, 2012
Study Start
November 1, 2012
Primary Completion
March 1, 2013
Study Completion
April 1, 2013
Last Updated
August 11, 2017
Record last verified: 2017-08