NCT01719016|Active Not Recruiting
Loading search results
Sponsor study identifier
observational
68
1 country
1
Study Start
August 2010
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
July 30, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
July 30, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Diagnosis of relative contributions of large artery blockages and microvascular blockages is very much needed in the treatment of coronary artery disease. In order to achieve this, two novel parameters, pressure drop coefficient (CDP), which combines flow and pressure readings and Lesion flow coefficient (LFC), which combines anatomical details of the lesion with pressure and flow readings, are being investigated.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
July 30, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
August 2010
Date type not reportedThis date has not been verified as actual or estimated.
October 29, 2012
Actual (reported)November 1, 2012
Actual (reported)July 30, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
July 30, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Quantification of relative contributions of large artery disease and microvascular disease
Correlation Coronary Flow Reserve (CFR) from Positron Emission Tomography (PET)imaging with diagnostic parameters, Pressure Drop Coefficient (CDP) and Lesion Flow Coefficient (LFC).
2 years
Quantification of relative contributions of large artery disease and microvascular disease
2 years
Cardiac PET scan: 1. Injection of N-13 Ammonia radionuclide. 2 doses of 10 milliCuries and 20 milliCuries each. 2. Injection of Lexiscan. Coronary catheterization: 1. Pressure and flow readings using Combowire 2. Injection of Adenosine.
Patients would under go a Cardiac rest and stress PET scan and include the following drug administration: 1. N-13 Ammonia radionuclide - Two doses, 10 mCi for rest, 20 mCi for stress 2. Lexiscan - stress agent for PET scan Patients would also undergo Coronary catheterization including the following drug administration and device usage: 1. Combowire to obtain pressure and flow readings on Combomap machine (Volcano Therapeutics, CA). 2. Adenosine - stress agent during catheterization, 140 ug/Kg/min
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Patients with chest pain and suspected ischemia that needs to be assessed by a stress test
Cincinnati Veteran Affairs Medical Center
Cincinnati, Ohio, 45220, United States
Banerjee RK, Ramadurai S, Manegaonkar SM, Rao MB, Rakkimuthu S, Effat MA. Comparison Between 5- and 1-Year Outcomes Using Cutoff Values of Pressure Drop Coefficient and Fractional Flow Reserve for Diagnosing Coronary Artery Diseases. Front Physiol. 2021 Jul 14;12:689517. doi: 10.3389/fphys.2021.689517. eCollection 2021.
Rupak K Banerjee, PhD
University of Cincinnati , CVAMC
Mohamed Effat, MD
Univesity of Cincinnati, University Hospital
Imran Arif, MD
University of Cincinnati and University Hospital
Hanan Kerr, MD
University of Cincinnati
68 participants (actual enrollment reported by the registry).
First Submitted
October 29, 2012
First Posted
November 1, 2012
Study Start
August 2010
Date type not reportedThis date has not been verified as actual or estimated.
Comparison of Intravenous Adenosine Infusion With Regadenoson Bolus for Inducing Maximal Coronary Hyperemia
Contact the study team to confirm eligibility.
Primary Completion
July 30, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
July 30, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
September 4, 2026
Record last verified: 2026-09
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.
Source retrieved: