NCT01715467

Brief Summary

This observational study will prospectively collect data on treatment options, patient/investigator satisfaction, requirement for retreatment or additional treatment, and long-term outcomes of 3 treatment modalities(XIAFLEX, fasciectomy, or fasciotomy/needle aponeurotomy) in patients with Dupuytren's contracture. In addition, this study will provide additional health economics and utilization data.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
162

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Sep 2012

Typical duration for all trials

Geographic Reach
1 country

27 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2012

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

October 25, 2012

Completed
4 days until next milestone

First Posted

Study publicly available on registry

October 29, 2012

Completed
1.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2014

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2014

Completed
Last Updated

June 16, 2015

Status Verified

June 1, 2015

Enrollment Period

2.1 years

First QC Date

October 25, 2012

Last Update Submit

June 12, 2015

Conditions

Keywords

DupuytrenContractureAuxiliumXIAFLEX

Outcome Measures

Primary Outcomes (1)

  • The primary objective is to collect real-world data regarding patient reported outcomes of the 3 primary treatment modalities in patients with Dupuytren's contracture.

    4 years

Secondary Outcomes (1)

  • Examine safety, effectiveness and association between treatments and selected healthcare utilization and patient report outcomes.

    4 years

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Community based sample

You may qualify if:

  • Women or men 18 years of age or older
  • Patients with a Dupuytren's contracture of at least a single joint and a desire for correction
  • Patients who are able to read and understand English
  • Patients who are capable of understanding and cooperating with the requirements of the study
  • Patients who are willing and able to respond to the posttreatment assessments via telephone or internet
  • Patients must provide written informed consent, indicating that they understand the purpose of and requirements of the study and are willing to participate in the study.

You may not qualify if:

  • Patients who decide not to pursue correction of the Dupuytren's contracture.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (27)

Raven Orthopaedics, Inc.

Burbank, California, 91505, United States

Location

Core Orthopaedic Medical Center

Encinitas, California, 92024, United States

Location

Torrey Pines Orthopaedic Medical Group

La Jolla, California, 92037, United States

Location

Brigid Freyne, MD, Inc.

Murrieta, California, 92563, United States

Location

Hand Surgery Associates

Denver, Colorado, 80210, United States

Location

Physicians for the Hand

Coral Gables, Florida, 33146, United States

Location

Florida Medical Research Institute

Lady Lake, Florida, 32159, United States

Location

Cleveland Clinic Florida

Weston, Florida, 33331, United States

Location

OrthoGeorgia

Macon, Georgia, 31201, United States

Location

Rockford Orthopedic Associates, LTD

Rockford, Illinois, 61107, United States

Location

Indiana Hand to Shoulder Center

Indianapolis, Indiana, 46260, United States

Location

The Hand Center

Wichita, Kansas, 67208, United States

Location

Bluegrass Orthopaedics and Hand Care Research

Lexington, Kentucky, 40509, United States

Location

Faith Regional Health Services

Norfolk, Nebraska, 68701, United States

Location

The Minimally Invasive Hand Institute

Las Vegas, Nevada, 89147, United States

Location

Central Jersey Hand Surgery

Eatontown, New Jersey, 07724, United States

Location

Comprehensive Hand Surgery PC

Brooklyn, New York, 11219, United States

Location

Beth Isreal Medical Center

New York, New York, 10003, United States

Location

Hospital for Special Surgery

New York, New York, 10021, United States

Location

Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27106, United States

Location

Steadman Hawkins Clinic of the Carolinas

Greenville, South Carolina, 29605, United States

Location

Core Orthopedics

Sioux Falls, South Dakota, 57103, United States

Location

The Plastic Surgery Group

Chattanooga, Tennessee, 37403, United States

Location

OrthoMemphis

Memphis, Tennessee, 38120, United States

Location

Vanderbilt Orthopaedic Institute

Nashville, Tennessee, 37232, United States

Location

Vanderbilt Orthopaedic Institute

Nashville, Tennessee, 37240, United States

Location

Charlottesville Orthopaedic Center, PLC

Charlottesville, Virginia, 22911, United States

Location

MeSH Terms

Conditions

Dupuytren ContractureContracture

Condition Hierarchy (Ancestors)

FibromaNeoplasms, Fibrous TissueNeoplasms, Connective TissueNeoplasms, Connective and Soft TissueNeoplasms by Histologic TypeNeoplasmsMuscular DiseasesMusculoskeletal DiseasesConnective Tissue DiseasesSkin and Connective Tissue DiseasesJoint Diseases

Study Officials

  • Urdaneta Veronica, MD

    Endo Pharmaceuticals

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 25, 2012

First Posted

October 29, 2012

Study Start

September 1, 2012

Primary Completion

October 1, 2014

Study Completion

October 1, 2014

Last Updated

June 16, 2015

Record last verified: 2015-06

Locations