Tests of Functional Magnetic Resonance Imaging Techniques

NCT01712633 | Terminated

• 2 other identifiers: 13000313-CC-0003
• Study Type: observational
• Target: 13
• Locations: 1 country
• Sites: 1

Brief Summary

Background: \- Functional magnetic resonance imaging (fMRI) is used to study the brain. It takes a series of pictures that can be used to look at how the brain processes information. It is used to study problems with thinking, language, and movement, among other things. Researchers are working to develop new and better fMRI techniques. To test these techniques, they want to perform fMRI scans on healthy volunteers. Objectives: \- To test different fMRI techniques in healthy volunteers. Eligibility: \- Healthy volunteers at least 18 years of age. Design:

• Participants will be screened with a physical exam and medical history.
• Participants will have fMRI scans of the brain. During these scans, they will be asked to perform simple tasks. These tasks may involve language, thinking, or motor skills. The scanning sessions will last up to 2 hours.
• Participants may be asked to return for additional fMRI scans over several years.

Conditions

Healthly Volunteers

Keywords

fMRI; Brain Perfusion

Outcome Measures

Primary Outcomes (1)

• evaluation of fMRI techniques

  To test different fMRI techniques in healthy volunteers.

  Study day 1, followup visit(s)

Study Arms (1)

Volunteers

Healthy Volunteers

Eligibility Criteria

• Age: 18 Years - 110 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Healthy volunteers willing to come to NIH or are already part of an existing NIH protocol.

You may qualify if:

• Healthy volunteers, new or from current NIH protocols are eligible. Healthy volunteers will be defined according the history obtained from reported medical history, medical record (reported at registration), the MRI safety questionnaire, and a clinical grade noncontrast brain MRI.
• Willing to travel to the NIH for follow-up visits
• Greater than 18 years old
• Able to understand and sign informed consent.
• Bilingual or multilingual subjects can participate in this study as long as the subjects are also fluent in English. Subjects do not need to be native or monolingual speakers of English.

You may not qualify if:

• The following criteria will be used to exclude subjects from participating in this protocol:
• Implanted metal clips or wires of the type which may concentrate radiofrequency fields or cause tissue damages from twisting in a Magnetic field. Examples:
• Aneurysm clip, implanted neural stimulator,
• Implanted cardiac pacemaker, defibrillator, or certain other implanted electrical or metallic devices,
• Cochlear implant, ocular foreign body (metal shavings),
• Any implanted device (pumps, infusion devices, etc.),
• Shrapnel injuries,
• History of metal in head or eyes or other parts of the body.
• Vagus Nerve Stimulators (VNS)
• Subjects with tattoos that contain metal.
• Pregnant women
• Over 350 lbs because of the weight limit of the MRI table
• Prior surgery that may render performing the MRI to be unsafe.
• Untreatable claustrophobia otherwise requiring anesthesia or antianxiety medications that may alter the subject s ability to perform the tasks during fMRI scanning.
• Subjects will be asked to refrain from drinking or eating caffeinated foods or drinks the morning of the scan that can result in vessel vasoconstriction prior to the scan.

Sponsors & Collaborators

• National Institutes of Health Clinical Center (CC): lead

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Hennig J, Speck O, Koch MA, Weiller C. Functional magnetic resonance imaging: a review of methodological aspects and clinical applications. J Magn Reson Imaging. 2003 Jul;18(1):1-15. doi: 10.1002/jmri.10330.

  PMID: 12815634 BACKGROUND

• Bennett CM, Miller MB. How reliable are the results from functional magnetic resonance imaging? Ann N Y Acad Sci. 2010 Mar;1191:133-55. doi: 10.1111/j.1749-6632.2010.05446.x.

  PMID: 20392279 BACKGROUND

• Pillai JJ. The evolution of clinical functional imaging during the past 2 decades and its current impact on neurosurgical planning. AJNR Am J Neuroradiol. 2010 Feb;31(2):219-25. doi: 10.3174/ajnr.A1845.

  PMID: 20150316 BACKGROUND

Related Links

• NIH Clinical Center Detailed Web Page

Study Officials

• Nadia M Biassou, M.D.

  National Institutes of Health Clinical Center (CC)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 20, 2012
• First Posted: October 23, 2012
• Study Start: March 19, 2015
• Primary Completion: November 1, 2017
• Study Completion: November 1, 2017
• Last Updated: November 22, 2021

Record last verified: 2021-11

Locations

US (1)