Web-based Intervention to Reduce Alcohol Use in Veterans With Hepatitis C
1 other identifier
interventional
138
1 country
2
Brief Summary
Many people who are infected with Hepatitis C misuse alcohol, which is even more dangerous for them than it is for a non-infected person. In this VA study, such individuals will be screened and given feedback on their drinking using an Internet-based program which has been shown to reduce drinking in other populations. The research team will evaluate whether the program helps Veterans drink less over time and thereby improve their health.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Mar 2015
Longer than P75 for not_applicable
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 3, 2012
CompletedFirst Posted
Study publicly available on registry
October 15, 2012
CompletedStudy Start
First participant enrolled
March 1, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 29, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
June 29, 2018
CompletedResults Posted
Study results publicly available
September 25, 2019
CompletedMarch 21, 2025
March 1, 2025
3.3 years
October 3, 2012
August 27, 2019
March 13, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Change in Days of Unhealthy Alcohol Consumption
The number of days on which alcohol was consumed beyond recommended levels in the last 30 days.
Baseline, 3 months, and 6 months
Change in Drinking Days
The number of days on which alcohol was consumed at any level in the last 30 days.
Baseline, 3 months, and 6 months
Secondary Outcomes (4)
Change in Drinks Per Drinking Day
Baseline, 3 months, and 6 months
Change in Symptoms of Psychological Distress (PHQ-9)
Baseline, 3 months, and 6 months
Change in SF-12 Physical Health Composite
Baseline, 3 months, and 6 months
Change in Additional Care
Baseline and 12 months
Other Outcomes (1)
Change in SF-12 Mental Health Composite
Baseline, 3 months, and 6 months
Study Arms (2)
BAI Arm
EXPERIMENTALReceiving a web-based brief intervention for alcohol problems
Usual Care
ACTIVE COMPARATORIn usual care, Hepatitis C clinic staff will sometimes discuss alcohol use with patients, and this will be the experience of some of the controls
Interventions
Participants report their alcohol use and problems on line and receive feedback comparing them to national norms.
All patients will be receiving care in a Hepatitis C clinic. In some cases clinicians may counsel them on alcohol problems.
Eligibility Criteria
You may qualify if:
- Must be a US military veteran.
- Over the age of 17 with liver disease.
- Must be receiving care at a VA liver clinic.
You may not qualify if:
- Those with no current or historical use of alcohol.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
VA Palo Alto Health Care System, Palo Alto, CA
Palo Alto, California, 94304-1290, United States
San Francisco VA Medical Center, San Francisco, CA
San Francisco, California, 94121, United States
Related Publications (6)
Timko C, Schultz NR, Cucciare MA, Vittorio L, Garrison-Diehn C. Retention in medication-assisted treatment for opiate dependence: A systematic review. J Addict Dis. 2016;35(1):22-35. doi: 10.1080/10550887.2016.1100960. Epub 2015 Oct 14.
PMID: 26467975BACKGROUNDCucciare MA, Timko C. Bridging the gap between medical settings and specialty addiction treatment. Addiction. 2015 Sep;110(9):1417-9. doi: 10.1111/add.12977. No abstract available.
PMID: 26223170RESULTCucciare MA, Cheung RC, Rongey C. Treating substance use disorders in patients with hepatitis C. Addiction. 2015 Jul;110(7):1057-9. doi: 10.1111/add.12893. Epub 2015 Mar 27. No abstract available.
PMID: 25816843RESULTTimko C, Kong C, Vittorio L, Cucciare MA. Screening and brief intervention for unhealthy substance use in patients with chronic medical conditions: a systematic review. J Clin Nurs. 2016 Nov;25(21-22):3131-3143. doi: 10.1111/jocn.13244. Epub 2016 May 3.
PMID: 27140392RESULTCucciare MA, Jamison AL, Combs AS, Joshi G, Cheung RC, Rongey C, Huggins J, Humphreys K. Adapting a computer-delivered brief alcohol intervention for veterans with Hepatitis C. Inform Health Soc Care. 2017 Dec;42(4):378-392. doi: 10.1080/17538157.2016.1255628. Epub 2017 Jan 9.
PMID: 28068154RESULTCucciare MA, Combs AS, Joshi G, Han X, Humphreys K. Computer-delivered brief alcohol intervention for patients with liver disease: a randomized controlled trial. Addiction. 2021 May;116(5):1076-1087. doi: 10.1111/add.15263. Epub 2020 Oct 6.
PMID: 32924207RESULT
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Dr. Micheal Cucciare
- Organization
- Department of Veterans Affairs
Study Officials
- PRINCIPAL INVESTIGATOR
Keith N. Humphreys, PhD MA
VA Palo Alto Health Care System, Palo Alto, CA
- PRINCIPAL INVESTIGATOR
Michael A Cucciare, PhD
Central Arkansas Veterans Healthcare System Eugene J. Towbin Healthcare Center, Little Rock, AR
Publication Agreements
- PI is Sponsor Employee
- Yes
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- FED
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
October 3, 2012
First Posted
October 15, 2012
Study Start
March 1, 2015
Primary Completion
June 29, 2018
Study Completion
June 29, 2018
Last Updated
March 21, 2025
Results First Posted
September 25, 2019
Record last verified: 2025-03
Data Sharing
- IPD Sharing
- Will not share