NCT01693458

Brief Summary

The Appreciative Inquiry Change Agents (CA) program (NAMWEZA) intends to address broad societal issues by engaging HIV-positive leaders as 'change agents' in their communities. In this study, the CAs will be recruited from an HIV Care and Treatment Centre in Dar es Salaam. The Namweza program has the potential to address structural issues related to HIV risk, such as access to limited resources, through an entrepreneurial component of the program. A positive, or appreciative, focus promotes CAs to examine assets in themselves and in their networks, encourages strengthening of relationships, and facilitates planning for a positive future for themselves, their families, and their communities. A stepped wedge randomized trial will be performed to evaluate the effectiveness of the program for the following primary outcomes: uptake of HIV services among network members of the CAs; rate of unprotected sex and frequency of concurrent relationships among CAs and their social networks; and levels of self-esteem, general self efficacy, and risk of intimate partner violence in the CAs. Secondary outcomes include: depressive symptoms, hopefulness, and HIV-related stigma (among CAs); social support and quality of relationships (among CAs); and HIV knowledge, attitudes and self-efficacy in preventing HIV transmission or re-infection (CAs and their networks). The following are primary hypotheses that will be tested through this stepped wedge randomized trial evaluation:

  1. 1.Uptake of HIV services will increase among individuals in the network of the HIV-positive Change Agents related to the intervention;
  2. 2.Levels of self-esteem and general self-efficacy will increase in trained Change Agents;
  3. 3.Rate of unprotected sex and number of concurrent partners will decrease (among network of Change Agents as well as Change Agents themselves; i.e. the 'study population'); and
  4. 4.Prevalence of intimate partner violence (IPV) will decrease in Change Agents.
  5. 5.Prevalence of depressive symptoms and HIV-related stigma will decrease and level of hopefulness will increase in trained Change Agents;
  6. 6.Levels of HIV knowledge, attitudes and self-efficacy in preventing HIV transmission and re-infection among CA and their networks will increase; and
  7. 7.Degree of social support and quality of relationships will improve among CA.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,046

participants targeted

Target at P75+ for phase_3

Timeline
Completed

Started Apr 2011

Typical duration for phase_3

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2011

Completed
1.3 years until next milestone

First Submitted

Initial submission to the registry

July 5, 2012

Completed
3 months until next milestone

First Posted

Study publicly available on registry

September 26, 2012

Completed
1.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2014

Completed
8 months until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2014

Completed
Last Updated

October 20, 2015

Status Verified

October 1, 2015

Enrollment Period

2.8 years

First QC Date

July 5, 2012

Last Update Submit

October 16, 2015

Conditions

Keywords

HIVpreventionHIV-positiveeducation

Outcome Measures

Primary Outcomes (1)

  • HIV Testing or other related-services for network members of HIV Positive change agents.

    Change in HIV Testing status (for those with unknown HIV status) or access to HIV services (for those who are HIV-positive, e.g. viral load, antiretroviral therapy, etc.)

    Baseline and every 4 months until end of study (4 times)

Secondary Outcomes (1)

  • Depressive symptoms

    Baseline, 4 months, 8 months, 12 months, 16 months

Study Arms (2)

Lifestyle counseling

EXPERIMENTAL

Appreciative Inquiry Change Agents (CA) Program (NAMWEZA)

Behavioral: Appreciative Inquiry Change Agents (CA) program (NAMWEZA)

Control group

PLACEBO COMPARATOR

Since the design is a stepped-wedge randomized trial, those in the control group will eventually receive the intervention later in the study.

Behavioral: Appreciative Inquiry Change Agents (CA) program (NAMWEZA)

Interventions

The intervention is based on an Appreciative Inquiry approach that comprises a 10-session program based on learning by doing rather than factual classroom type learning, although it includes discussion of relevant facts about HIV, and other STIs. The intervention is based on the template of Stepping Stones (Jewkes et al., 2008), which is internationally one of the most widely used participatory behavioral interventions targeting sexual health. The Stepping Stones curriculum was shortened and radically adapted from more than 20 sessions. However NAMWEZA borrows generously from many of the exercises and games. It also employs the successful experience of stratification by age and sex to engage 4 different working groups (younger and older, male and female).

Also known as: Positive Change Agents Program- Tanzania
Control groupLifestyle counseling

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • HIV-positive, receiving HIV care at Sinza CTC and on ART for at least 3 months (transfer-in patients who are on ART will be considered eligible);
  • lives in the catchment areas of the Kinondoni municipality and plans to remain in the area for at least two years;
  • greater than or equal to 18 years of age;
  • willingness to work with at least 20 members in their social network as a CA/educator in their community; and
  • willingness to invite up to 10 social network members for involvement in the network members (NM) program.
  • identified by CAs as at risk for HIV or intimate partner violence (IPV);
  • lives in Dar es Salaam and plans to remain in area for at least 2 years; and
  • greater than or equal to 18 years of age.

You may not qualify if:

  • not well enough to attend training; or
  • unable or unwilling to provide informed consent.
  • enrolled as a CTC patient at Sinza Health Facility or
  • enrolled as a NM for another CA

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Muhimbili University of Health and Allied Sciences

Dar es Salaam, Dar es Salaam Region, 255, Tanzania

Location

Related Publications (3)

  • Rewley J, Fawzi MCS, McAdam K, Kaaya S, Liu Y, Todd J, Andrew I, Onnela JP. Evaluating spillover of HIV knowledge from study participants to their network members in a stepped-wedge behavioural intervention in Tanzania. BMJ Open. 2020 Oct 7;10(10):e033759. doi: 10.1136/bmjopen-2019-033759.

  • Siril H, Smith Fawzi MC, Todd J, Somba M, Kaale A, Minja A, Killewo J, Mugusi F, Kaaya SF. The value of hope: development and validation of a contextual measure of hope among people living with HIV in urban Tanzania a mixed methods exploratory sequential study. BMC Psychol. 2020 Jan 29;8(1):5. doi: 10.1186/s40359-020-0376-y.

  • Smith Fawzi MC, Siril H, Liu Y, McAdam K, Ainebyona D, McAdam E, Somba M, Oljemark K, Mleli N, Lienert J, Andrew I, Haberlen S, Simwinga A, Todd J, Makongwa S, Li N, Kaaya S. Agents of change among people living with HIV and their social networks: stepped-wedge randomised controlled trial of the NAMWEZA intervention in Dar es Salaam, Tanzania. BMJ Glob Health. 2019 May 9;4(3):e000946. doi: 10.1136/bmjgh-2018-000946. eCollection 2019.

MeSH Terms

Conditions

HIV InfectionsHIV Seropositivity

Condition Hierarchy (Ancestors)

Blood-Borne InfectionsCommunicable DiseasesInfectionsSexually Transmitted Diseases, ViralSexually Transmitted DiseasesLentivirus InfectionsRetroviridae InfectionsRNA Virus InfectionsVirus DiseasesGenital DiseasesUrogenital DiseasesImmunologic Deficiency SyndromesImmune System Diseases

Study Officials

  • Mary C. Smith Fawzi, ScD

    Harvard Medical School (HMS and HSDM)

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

July 5, 2012

First Posted

September 26, 2012

Study Start

April 1, 2011

Primary Completion

January 1, 2014

Study Completion

September 1, 2014

Last Updated

October 20, 2015

Record last verified: 2015-10

Locations