NCT01691950

Brief Summary

This is an observational study, which aims to firstly develop a sensor-based objective mobility assessment. This will then be used to profile and compare the outcomes of patients who undergo amputation with those who have limb salvage surgery following a traumatic injury to their lower limb.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Apr 2012

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2012

Completed
22 days until next milestone

First Submitted

Initial submission to the registry

April 23, 2012

Completed
5 months until next milestone

First Posted

Study publicly available on registry

September 25, 2012

Completed
1.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2014

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2014

Completed
5.4 years until next milestone

Results Posted

Study results publicly available

August 20, 2019

Completed
Last Updated

February 20, 2020

Status Verified

February 1, 2020

Enrollment Period

2 years

First QC Date

April 23, 2012

Results QC Date

February 21, 2019

Last Update Submit

February 11, 2020

Conditions

Keywords

TraumaLimb reconstructionAmputationFunctional outcomeSensing

Outcome Measures

Primary Outcomes (1)

  • Functional Outcome (Consisting of Questionnaire Score, Hamlyn Mobility Score (HMS) Gait/Activities of Daily Living Parameters)

    The Hamlyn Mobility Score is a measure of functional mobility as measured by a wearable sensors during simple physical activities. The score range is from 0 - 60, with 60 being the best score possible and represents normal physical function of a healthy adult.

    3 months post-reconstruction

Secondary Outcomes (1)

  • Participant Length of Hospital Stay

    Up to length of study (1-2 years)

Study Arms (2)

Reconstruction

Those who have undergone limb reconstruction following lower limb trauma

Healthy volunteers

Healthy volunteers for control

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Participants who have been treated following lower limb trauma at the Imperial College NHS Trust sites will be recruited for this study.

You may qualify if:

  • To have sustained a lower-limb trauma and undergone limb salvage surgery OR amputation with fitting of prosthesis

You may not qualify if:

  • Contralateral (or other) limb impairment
  • \> AGE \> 65
  • Currently a hospital inpatient
  • Psychological disorder

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Imperial College NHS Trust

London, W2 1NY, United Kingdom

Location

MeSH Terms

Conditions

Wounds and Injuries

Limitations and Caveats

The trial recruited 0 patients with prostheses and as such this study arm has been deleted.

Results Point of Contact

Title
Mr Richard M Kwasnicki PhD MRCS
Organization
Imperial College London

Study Officials

  • Richard M Kwasnicki, BSc (Hons)

    Imperial College London

    PRINCIPAL INVESTIGATOR
  • Shehan Hettiaratchy, PhD, FRCS

    Imperial College London

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
Yes

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
OTHER
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 23, 2012

First Posted

September 25, 2012

Study Start

April 1, 2012

Primary Completion

April 1, 2014

Study Completion

April 1, 2014

Last Updated

February 20, 2020

Results First Posted

August 20, 2019

Record last verified: 2020-02

Data Sharing

IPD Sharing
Will not share

Locations