Evaluating the Effectiveness of Interactive SMS Reminders on TB Treatment Outcomes
Monitoring Patient Compliance With Tuberculosis Treatment Regimens
1 other identifier
interventional
2,207
1 country
11
Brief Summary
In this study, Interactive Research and Development (IRD) in Karachi, Pakistan is evaluating the impact of Interactive Reminders on drug compliance and treatment outcomes. Interactive Reminders is an interactive SMS reminder system to help patients remember to take their TB medication. In this system, patients receive daily SMS reminders for the duration of their treatment at a pre-specified time, reminding them to take their medication. Patients are asked to reply back to the system, either through SMS or a missed call, with the time they took their medicine that day. If a response is not received within two hours, a second reminder is sent. If a response is still not received in a further two hours, a third and final reminder for the day is sent. Non-responsive patients are followed up with phone calls and a list of non-responsive patients is shared with clinics based on the parameters of non-responsiveness that they specify. IRD seeks to determine the impact of this system on treatment outcomes and compliance to prescribed medication through administering a randomized control trial among newly diagnosed TB patients in Karachi, Pakistan.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Mar 2011
Longer than P75 for not_applicable
11 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2011
CompletedFirst Submitted
Initial submission to the registry
September 13, 2012
CompletedFirst Posted
Study publicly available on registry
September 24, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2014
CompletedMarch 20, 2015
March 1, 2015
3.7 years
September 13, 2012
March 18, 2015
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Treatment Outcomes
The investigators will compare clinically reported treatment outcomes between the intervention and control groups.
After 6 to 8 months of treatment
Secondary Outcomes (4)
Physical fitness and mobility
Monthly visits for 6 to 8 months of treatment
Psychological Impacts
Monthly visits for 6 to 8 months of treatment
Self-reported medication adherence
"Surprise" monthly visits during treatment
Sputum conversion
At 1, 2, 5, and 6/7 months of treatment
Study Arms (2)
Control
NO INTERVENTIONThis arm will receive the regular standard of care given by TB clinics.
Interactive Reminders
EXPERIMENTALPatients randomized to this arm will receive Interactive SMS reminders daily.
Interventions
Daily SMS reminders sent to TB patients at a pre-specified time. They are asked to respond to the reminders. If a response is not received within two hours, they are sent another reminder for up to three per day.
Eligibility Criteria
You may qualify if:
- New, smear-positive drug susceptible TB who have been on treatment for less than two weeks
- Access to a mobile phone (self-reported)
- Intending to reside in Karachi for the duration of their treatment
You may not qualify if:
- Patients who do not have regular access to a mobile phone
- Patients who have previously received TB treatment
- Patients who have another member in their household who is already a part of the study
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (11)
Civil Hospital
Karachi, Pakistan
Indus Hospital
Karachi, Pakistan
Jinnah Postgraduate Medical Center
Karachi, Pakistan
Landhi Medical Complex
Karachi, Pakistan
Private GP clinics and Private labs partnering with Interactive Research and Devellopment
Karachi, Pakistan
Sindh Government Hospital - Liaqatabad
Karachi, Pakistan
Sindh Government Hospital - New Karachi
Karachi, Pakistan
Sindh Government Hospital - Qatar
Karachi, Pakistan
Sindh Government Hospital New Karachi Kaali Market
Karachi, Pakistan
UHC-New Karachi
Karachi, Pakistan
Urban Health Center - Landhi
Karachi, Pakistan
Related Publications (1)
Mohammed S, Glennerster R, Khan AJ. Impact of a Daily SMS Medication Reminder System on Tuberculosis Treatment Outcomes: A Randomized Controlled Trial. PLoS One. 2016 Nov 1;11(11):e0162944. doi: 10.1371/journal.pone.0162944. eCollection 2016.
PMID: 27802283DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Rachel Glennerster, PhD.
Massachusetts Institute of Technology
- PRINCIPAL INVESTIGATOR
Shama Mohammed, MPA/ID
Interactive Research and Development
- PRINCIPAL INVESTIGATOR
Aamir J. Khan, MD/PhD.
Interactive Research and Development
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- SUPPORTIVE CARE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Researcher
Study Record Dates
First Submitted
September 13, 2012
First Posted
September 24, 2012
Study Start
March 1, 2011
Primary Completion
November 1, 2014
Study Completion
November 1, 2014
Last Updated
March 20, 2015
Record last verified: 2015-03