NCT01688219

Brief Summary

The aetiology of SAPHO syndrome seems to involve genetic, infectious and immunological components. The investigators examined innate and adaptative immune responses in SAPHO syndrome as compared with psoriatic arthritis and rheumatoid arthritis.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
39

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Nov 2005

Typical duration for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2005

Completed
2.5 years until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2008

Completed
4.4 years until next milestone

First Submitted

Initial submission to the registry

September 14, 2012

Completed
5 days until next milestone

First Posted

Study publicly available on registry

September 19, 2012

Completed
Last Updated

September 19, 2012

Status Verified

October 1, 2007

First QC Date

September 14, 2012

Last Update Submit

September 18, 2012

Conditions

SAPHO Syndrome

Keywords

SAPHO syndromeInnate immunityTNF alphaPolymorphonuclear neutrophilsPropionibacterium acnesInterleukin-8

Outcome Measures

Primary Outcomes (1)

  • IL-8 production by PMN

    24 h

Secondary Outcomes (1)

  • TNFalpha production by PMN

    24 h

Eligibility Criteria

Age1 Year - 70 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

SAPHO syndrome patients

You may qualify if:

  • Clinical diagnosis of SAPHO syndrome
  • Must have bone lesions

You may not qualify if:

  • Infliximab treatment

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Acquired Hyperostosis Syndrome

Condition Hierarchy (Ancestors)

OsteochondrodysplasiasBone Diseases, DevelopmentalBone DiseasesMusculoskeletal Diseases

Study Officials

  • Gilles Hayem, PhD

    Assitance Publique-Hopitaux Paris

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 14, 2012

First Posted

September 19, 2012

Study Start

November 1, 2005

Study Completion

May 1, 2008

Last Updated

September 19, 2012

Record last verified: 2007-10