Epigenomic Dysregulation in Preeclampsia-Associated Chronic Hypertension

NCT01682304 | Completed

• 1 other identifier: GFHNRC611
• Study Type: observational
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

Preliminary data from the investigator's lab identified novel patterns of differential DNA methylation in genes regulating cardiovascular and metabolic function in blood from women during the first trimester of pregnancy who were destined to develop preeclampsia (PE) in the third trimester. Further, common patterns of differential DNA methylation were found in the common genes from placental tissue at time of birth in the same women after diagnosis with PE, suggesting that the epigenomic patterns that predict pregnancy-induced hypertension may also underlie the development of chronic hypertension years after. It is unknown whether aberrant DNA methylation in pregnancy-induced hypertension is the mechanism by which chronic hypertension develops in these women remote from pregnancy nor is it known if hypertension remote from PE is as responsive to therapeutic treatment of hypertension compared to women who develop hypertension without history of PE. The investigators plan to objectively test the central hypothesis and attain the objective of this project

Conditions

Preeclampsia; Hypertension; Pregnancy Induced Hypertension

Keywords

preeclampsia; hypertension; blood pressure; pregnancy induced hypertension; chronic hypertension

Outcome Measures

Primary Outcomes (1)

• DNA methylation pattern

  Determine DNA methylatiion patterns in women with hypertension who have/have not had a prior diagnosis of preeclampsia

  age 30-65

Secondary Outcomes (1)

• Vascular function

  aged 30-65

Study Arms (1)

History of Preeclampsia

Chronic hypertension with history of preeclampsia Chronic hypertension without history of preeclampsia

Eligibility Criteria

• Age: 30 Years - 65 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Females diagnosed with chronic hypertension with a prior pregnancy

You may qualify if:

• Female gender
• history of prior pregnancy
• diagnosis of chronic hypertension
• current treatment of chronic hypertension
• age 30 - 50 years old

You may not qualify if:

• presence of comorbid conditions that influence cardiovascular health (SLE, congenital cardiac anomalies

Sponsors & Collaborators

• Ohio State University: lead

Study Sites (1)

The Ohio State University

Columbus, Ohio, 43210, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

Sputum and peripheral blood will be collected for DNA extraction and epigenetic analyses.

MeSH Terms

Conditions

Pre-Eclampsia; Hypertension; Hypertension, Pregnancy-Induced

Condition Hierarchy (Ancestors)

Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Cindy M Anderson, PhD

  Ohio State University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD, WHNP-BC, FAAN

Study Record Dates

• First Submitted: September 5, 2012
• First Posted: September 10, 2012
• Study Start: May 1, 2012
• Primary Completion: March 1, 2014
• Study Completion: March 1, 2014
• Last Updated: October 12, 2022

Record last verified: 2022-10

Locations

US (1)