Investigation of Stem Cells in Human Lipoaspirate
Investigation of Adipose-Derived Stem Cells in Human Lipoaspirate
1 other identifier
observational
240
1 country
1
Brief Summary
The overall purpose of this study is to enhance identification and isolation of ADSCs and adipocytes, to find the optimum culturing conditions to increase growth and volume of grafts, and to study the effects of cryopreservation on ADSCs and adipocytes. Fat injections are used in aesthetic surgery but tend to disassemble over time. If the investigators can enhance growth and volume of fat in culture, the investigators could use fat grafts in reconstruction of cancer and traumatic injury defects with the patients own cultured fat cells and grafts.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Mar 2011
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2011
CompletedFirst Submitted
Initial submission to the registry
August 28, 2012
CompletedFirst Posted
Study publicly available on registry
September 3, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2018
CompletedJanuary 9, 2015
January 1, 2015
7.4 years
August 28, 2012
January 8, 2015
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Percent of Viable ADSCs
Percent of viable ADSCs will be measured on fresh samples and samples refrigerated for different times.
Day of Surgery
Secondary Outcomes (1)
Percent of Apoptotic ADSCs
Day of Surgery
Other Outcomes (1)
Percent of Necrotic ADSCs
Day of Surgery
Study Arms (1)
18-30 yrs, 31-50 yrs, 51-70 yrs
No intervention
Eligibility Criteria
Primary Care Clinic
You may qualify if:
- All adults (18-70 yrs) who have scheduled surgical lipectomy of the hips, abdomen, or thighs are prospective subjects for this study.
You may not qualify if:
- Pregnant women will be excluded to protect the unborn child.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Nevada School of Medicine Patient Care Center
Las Vegas, Nevada, 89102, United States
Biospecimen
Cells from lipoaspirate maximum of 20 days
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
William A Zamboni, M.D.
UNSOM
- STUDY DIRECTOR
Wei Z Wang, M.D.
wwang@medicine.nevada.edu
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor and Chair Department of Surgery UNSOM
Study Record Dates
First Submitted
August 28, 2012
First Posted
September 3, 2012
Study Start
March 1, 2011
Primary Completion
August 1, 2018
Study Completion
August 1, 2018
Last Updated
January 9, 2015
Record last verified: 2015-01