Factors Associated With Interdialytic Blood Pressure Variability in Maintenance Hemodialysis Patients

NCT01674660 | Unknown

• 2 other identifiers: BeijingCYH19860805
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to explore the factors associated with interdialytic blood pressure variability in maintenance hemodialysis patients, especially the association between volume status and blood pressure variability.

Conditions

Kidney Failure, Chronic

Keywords

hemodialysis; blood pressure variability; volume status

Outcome Measures

Primary Outcomes (1)

• interdialytic blood pressure

  Ambulatory BP monitoring was performed after the midweek hemodialysis session for 44 hours. Ambulatory BPs were recorded every 20 minutes during the day (6 AM to 10 PM) and every 30 minutes during the night (10 PM to 6 AM) in the nonaccess arm, We use the coefficient of variation or standard deviation in interdialytic blood pressure as a indicator of systolic blood pressure variability.

  44 hours

Study Arms (3)

volume status

volume status:group1 over volume status,group2 normal volume status,group3 low volume status

night blood pressure

night blood pressure：group1 nondipper,group2 dipper,group3 extreme dipper,group4 riser

interdialysis weight gain

interdialysis weight gain:group1 \>5% dry weight,group2 \<5% dry weight

Eligibility Criteria

• Age: 24 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

hemodialysis patients of Beijing Chaoyang Hospital

You may qualify if:

• age 18 years or older
• receipt of thrice-weekly in-center hemodialysis
• no anticipation of imminent(\<6 months)living related kidney transplant
• not transfer of care to a nonparticipating facility
• no dialytic modality change

You may not qualify if:

• who missed \>2 hemodialysis treatments over 1 month
• abused drugs
• severe anemia，malnutrition，chronic atrial fibrillation
• body mass index of 40 \>kg/m2

Sponsors & Collaborators

• Beijing Chao Yang Hospital: lead

Study Sites (1)

Nephrology, dialysis center,Beijing Chaoyang Hospital

Beijing, Beijing Municipality, 100020, China

Location

Biospecimen

Retention: SAMPLES WITH DNA

whole blood, serum, white cells, urine.

MeSH Terms

Conditions

Kidney Failure, Chronic

Condition Hierarchy (Ancestors)

Renal Insufficiency, Chronic; Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Ma WH weihua, Master

  Beijing Chao Yang Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Cui TG Taigen, Dr.

CONTACT

010-85231510; fujine_521@sina.com

Ma WH Weihua, Master

CONTACT

010-85231952; maweihua_521@sina.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigater

Study Record Dates

• First Submitted: August 21, 2012
• First Posted: August 29, 2012
• Study Start: September 1, 2012
• Primary Completion: January 1, 2013
• Study Completion: March 1, 2013
• Last Updated: August 31, 2012

Record last verified: 2012-08

Locations

CN (1)