NCT01674023

Brief Summary

MicroRNAs are important regulators of many cellular functions but their expression profile in human vitreous is still unclear. Aim of this study is to investigate microRNA expression profile by PCR in human vitreous of patients with various vitreoretinal disorders and compare with that of patients with macular holes which are suggested to be similar to that of healthy subjects.

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
8

participants targeted

Target at below P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 2012

Completed
22 days until next milestone

First Submitted

Initial submission to the registry

August 23, 2012

Completed
5 days until next milestone

First Posted

Study publicly available on registry

August 28, 2012

Completed
2.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2014

Completed
Last Updated

April 1, 2015

Status Verified

March 1, 2015

Enrollment Period

2.3 years

First QC Date

August 23, 2012

Last Update Submit

March 31, 2015

Conditions

MicroRNA Expression Profile in Human Vitreous of Various Vitreoretinal Diseases

Outcome Measures

Primary Outcomes (1)

  • MicroRNA expression profile in human vitreous investigated by PCR

    1month

Study Arms (1)

human vitreous, human blood serum, PCR

human vitreous and blood serum sampling, PCR 1ml of human vitreous and 3ml of human blood serum of patients with various vitreoretinal diseases

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Pateints undergoing vitrectomy for various vitreoretinal disesases

You may qualify if:

  • any patients undergoing vitrectomy for various vitreoretinal diseases

You may not qualify if:

  • previously vitrectomized eyes

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Kyorin University School Of Medicine

Mitakasi Sinkawa6-20-2, Tokyo, 181-8611, Japan

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

3ml of blood serum and 1ml of vitreous

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
MD

Study Record Dates

First Submitted

August 23, 2012

First Posted

August 28, 2012

Study Start

August 1, 2012

Primary Completion

December 1, 2014

Last Updated

April 1, 2015

Record last verified: 2015-03

Locations

JP(1)