Diagnosis and Treatment of Minor Ischaemic Stroke According to the Etiology and Pathogenesis

NCT01665729 | Unknown DMC

• 1 other identifier: 2011-2-48
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 1

Brief Summary

Negligence or contempt of the etiology and pathogenesis of minor ischaemic stroke in the early diagnosis and effective treatment leads to more than 40-50% of patient with recurrent episodes, and 10% patient died. Therefore, diagnosis and treatment of minor ischaemic stroke according to the etiology and pathogenesis is important. The 2007 Korean modified TOAST type got some progress, but there exists two major disadvantages: imperfect diagnosis and pathogenesis of perforator artery infarction etiology; lack of typing according to the pathogenesis of large atherosclerotic infarction and taking measures of treatment according to the new types. Recently, domestic professor Gaoshan proposes new approach to diagnose and treat minor ischaemic stroke according to the etiology and pathogenesis of CISS typing, but the pathogenesis of hypoperfusion infarction with severe stenosis of large artery is unclear. Is it low perfusion? Or artery-artery embolization? Or both? How to distinguish the pathogenesis of branch artery disease: by atherosclerosis? Or hyalinosis? Or both? How to check the validity of clinical types? This study take different interventions according to different types and observation of the long term clinical results of intervention( mortality, recurrence rate, disability rate and rate of cerebral hemorrhage and subarachnoid hemorrhage), in order to clarify the new types can indeed solve the current problem of minor ischaemic stroke with high mortality, recurrence rate, disability rate and rate of cerebral hemorrhage and subarachnoid hemorrhage.

Conditions

Ischaemic Stroke

Keywords

etiology; pathogenesis; minor ischaemic stroke; types; intervention

Study Arms (3)

artery-artery embolus

There is no hypoperfusion ( contralateral compensatory is good )

Hypoperfusion

Contralateral compensatory not sufficient

Hypoperfusion and embolus amotic

Hypoperfusion and embolus amotic

Eligibility Criteria

• Age: 20 Years - 79 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

patients with new emergence of minor ischaemic stroke ( one of two conditions: (1) conscious patients with any of NIHSS score = 1,or (2) NIHSS ≤ 3 )

You may qualify if:

• one of two conditions:
• conscious patients with any of NIHSS score = 1,or
• NIHSS ≤ 3

You may not qualify if:

• patients Over 80 years of age
• patients With serious heart, lung, liver, kidney dysfunction or
• severe systemic complications,
• a known tumor,
• pregnancy,
• having a history of cerebral hemorrhage

Sponsors & Collaborators

• Li Haiyan: lead

Study Sites (1)

Department of Neurology,The Third Affiliated Hospital of Sun yat-sen University

Guangzhou, Guangdong, 510630, China

RECRUITING

MeSH Terms

Conditions

Ischemic Stroke

Condition Hierarchy (Ancestors)

Stroke; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Zhengqi Lu, prof.

  Department of Neurology,The Third Affiliated Hospital of Sun yat-sen University

  STUDY CHAIR

Central Study Contacts

Zhengqi Lu, prof.

CONTACT

86 13570102668; lzq1828@yahoo.com.cn

Haiyan Li, Dr.

CONTACT

86 15920474159; lihaiyan162@yahoo.com.cn

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Dr.

Study Record Dates

• First Submitted: August 12, 2012
• First Posted: August 15, 2012
• Study Start: June 1, 2011
• Primary Completion: August 1, 2012
• Study Completion: December 1, 2015
• Last Updated: August 15, 2012

Record last verified: 2012-08

Locations

CN (1)