Neural, Behavioral and Physiological Correlates of Feeding in Humans

NCT01665560 | Completed DMC

• 1 other identifier: 0505027690
• Study Type: observational
• Target: 27
• Locations: 1 country
• Sites: 1

Brief Summary

The overarching goal of this project is to understand how nicotine addiction interacts with feeding behaviors and brain representation of food reward. The current proposal is part of a larger effort to begin a program of research to elucidate similarities and differences in perception of, and behavioral and neural response to, food and cigarette aromas as a function of 1) smoking status (smokers, ex-smokers who do gain weight, ex-smokers who do not gain weight, non-smokers), 2) internal state (hungry, full), and 3) cigarette deprivation (acute, chronic). A general hypothesis is that there are overlapping neural mechanisms governing food reward and cigarette reward in smokers and that this overlap includes incentive salience encoding.

Conditions

Magnetic Resonance Imaging, Functional

Keywords

smoking; fMRI; odors; taste

Outcome Measures

Primary Outcomes (1)

• fMRI w/ taste and smell stimuli

  Subjects will be scanned on a 3T Trio magnet while tasting and smelling various food and non-food substances. Our primary outcome measure will be differential brain responses to taste and smell stimuli as a function of group (smokers vs. nonsmokers).

  1-2 hours

Study Arms (2)

Smokers--Currently Smoking

Individuals that are right handed, and not claustrophobic were recruited. This same group was used for the smoking-group and refrain from smoking was evaluated by CO2 evaluation. To be classified as smokers, they had to report smoking 3-10 cigarettes daily for at least the last year and have a carbon monoxide reading of CO \>10 ppm.

Non-Smoker

Healthy individuals meeting the inclusion criteria who claim to not smoke. This is confirmed w/ CO testing.

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Healthy adults in the New Haven, CT area.

You may qualify if:

• Healthy
• between the ages of 18-45
• fMRI safe

You may not qualify if:

• outside of the above age range
• not able to have an fMRI (non-removable metal, pacemaker, etc)
• medical diagnosis related to neurological problems, anxiety, psychiatric conditions
• Did not refrain from smoking for the described time in the smoking group, or showed a CO2 level consistent with a smoker in the non-smoking group

Sponsors & Collaborators

• Yale University: lead

Study Sites (1)

John B Pierce Laboratory

New Haven, Connecticut, 06519, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

saliva samples were obtained and are stored using a coded ID in a secure part of our facility

MeSH Terms

Conditions

Smoking

Condition Hierarchy (Ancestors)

Behavior

Study Officials

• Dana M Small, PhD

  Yale & John B Pierce Laboratory

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 2, 2012
• First Posted: August 15, 2012
• Study Start: June 1, 2005
• Primary Completion: July 1, 2009
• Study Completion: July 1, 2009
• Last Updated: August 15, 2012

Record last verified: 2012-08

Locations

US (1)