CT Calcium Scoring in Suspected Stable Angina
Comparison of CT Coronary Artery Calcium Scoring With Traditional Assessment in Patients Presenting to the Rapid Access Chest Pain Clinic With Non-acute Chest Pain and Its Prognostic Value
1 other identifier
observational
705
1 country
1
Brief Summary
Patients with stable chest pain presenting to general practitioners in UK are routinely referred to the chest pain clinics in the hospitals. They are assessed by clinical history including risk factors, cardiovascular exam, resting ECG, chest x-ray, and exercise ECG. CT calcium scoring (CTCS) is a technique that is very sensitive in identifying and quantifying calcified atherosclerotic plaques. Recent guidance from the National Institute of Clinical Excellence (NICE, citation 1) proposes the use of CTCS in patients with stable chest pain who have low likelihood of coronary artery disease (CAD). They recommend that patients with low likelihood (10-30%) have a CTCS and if the score is 0, they can be considered to have non-cardiac chest pain. However, there is controversy regarding relationship of absent calcification with significant CAD and its prognostic value. At our institution, we have been performing CTCS in this patient cohort since 2003. We plan to retrospectively review the usefulness in CTCS in patients with different likelihood for significant CAD, particularly in patients with absent calcium and compare with the traditional assessment. We also plan to follow-up these patients for any myocardial infarction and death from any cause.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2011
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2011
CompletedFirst Submitted
Initial submission to the registry
August 6, 2012
CompletedFirst Posted
Study publicly available on registry
August 8, 2012
CompletedAugust 9, 2012
August 1, 2012
6 months
August 6, 2012
August 8, 2012
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
All-cause mortality
7 years
Secondary Outcomes (1)
Non-fatal myocardial infarction
7 years
Other Outcomes (1)
Obstructed coronary artery disease
3 months
Study Arms (1)
Stable chest pain
All patients presenting with stable chest pain and referred by their general practitioners to the chest pain clinic in the hospital who had CT calcium scoring performed besides standard assessment.
Interventions
CT Calcium scoring was performed in the patients as an imaging test in addition to the traditional assessment on the same day of patients attending the chest pain clinic on the first visit. This was performed with standard protocol and the absolute calcium score was calculated.
Eligibility Criteria
Patients who presented to our chest pain clinic between October 2003 to March 2010 with stable (non-acute) chest pain and assessed with history, physical examination, cardiovascular risk factors, chest X-ray, 12-lead resting ECG and exercise ECG.
You may qualify if:
- non-acute chest pain
- those who underwent CT calcium scoring
- availability of all relevant risk factor information
You may not qualify if:
- previous coronary disease i.e., myocardial infarction or revascularization
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Harefield Hospital
London, Middlesex, UB9 6JH, United Kingdom
Related Publications (1)
Skinner JS, Smeeth L, Kendall JM, Adams PC, Timmis A; Chest Pain Guideline Development Group. NICE guidance. Chest pain of recent onset: assessment and diagnosis of recent onset chest pain or discomfort of suspected cardiac origin. Heart. 2010 Jun;96(12):974-8. doi: 10.1136/hrt.2009.190066. No abstract available.
PMID: 20538674BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 6, 2012
First Posted
August 8, 2012
Study Start
June 1, 2011
Primary Completion
December 1, 2011
Study Completion
December 1, 2011
Last Updated
August 9, 2012
Record last verified: 2012-08