P. Gingivalis IgG Titer Test for Periodontitis
Assessment of Use of Plasma or Serum IgG Test to Screen for Periodontitis
2 other identifiers
observational
1,387
1 country
12
Brief Summary
This study was performed to evaluate prospectively the diagnostic utility of a blood IgG antibody titer test against periodontal pathogens.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2007
Typical duration for all trials
12 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2009
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2010
CompletedFirst Submitted
Initial submission to the registry
July 31, 2012
CompletedFirst Posted
Study publicly available on registry
August 7, 2012
CompletedAugust 7, 2012
August 1, 2012
2.8 years
July 31, 2012
August 2, 2012
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Level of IgG antibodies in serum/plasma against periodontal pathogens
Serum/plasma samples will be screened for the presence of IgG antibodies against the below mentioned periodontal pathogens, using the "ELISA" method. Aggregatibacter actinomycetemcomitans, Eikenella corrodens, Prevotella intermedius, Porphyromonas gingivalis
1 to 3 months after basic periodontal treatment (Scaling and root planing)
Secondary Outcomes (3)
Periodontal pocket depth
1 to 3 months after basic periodontal treatment
Bleeding on probing
1 to 3 monthsafter basic periodontal treatment
Tooth mobility
1 to 3 months after basic periodontal treatment
Study Arms (1)
periodontitis
those with periodontitis and those without periodontitis
Eligibility Criteria
Patients who visit university hospitals to receive periodontal treatment are patients group. Employees who receive occupational health check at a company facility.
You may qualify if:
- periodontal patients
- adults
You may not qualify if:
- difficulty of communication
- received periodontal therapy within 3 months
- with other diseases, i.e., hypertension, diabetes (self reported)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (12)
Aichi Gakuin University, School of Dentistry
Nagoya, Aichi-ken, 4648650, Japan
Toyota Motor Corporation
Toyota, Aichi-ken, 4442225, Japan
Nihon University School of Dentistry at Matsudo
Matsudo, Chiba, 2718587, Japan
Hiroshima University Graduate School of Biomedical Sciences
Hiroshima, Hiroshima, 7348553, Japan
Tohoku University Graduate School of Dentistry
Sendai, Miyagi, 9808575, Japan
Nagasaki University Graduate School of Biomedical Sciences
Nagasaki, Nagasaki, 8528588, Japan
Niigata University Faculty of Dentistry
Niigata, Niigata, 9518514, Japan
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Okayama, Okayama-ken, 7008525, Japan
Osaka University Graduate School of Dentistry
Suita, Osaka, 5650871, Japan
The University of Tokushima Graduate School, Institute of Health Biosciences
Tokushima, Tokushima, 7708504, Japan
Tokyo Medical and Dental University Graduate School
Bunkyo-ku, Tokyo, 1138510, Japan
Nippon Dental University, School of Life Dentistry at Tokyo
Chiyoda-ku, Tokyo, 1020071, Japan
Related Publications (1)
Kudo C, Naruishi K, Maeda H, Abiko Y, Hino T, Iwata M, Mitsuhashi C, Murakami S, Nagasawa T, Nagata T, Yoneda S, Nomura Y, Noguchi T, Numabe Y, Ogata Y, Sato T, Shimauchi H, Yamazaki K, Yoshimura A, Takashiba S. Assessment of the plasma/serum IgG test to screen for periodontitis. J Dent Res. 2012 Dec;91(12):1190-5. doi: 10.1177/0022034512461796. Epub 2012 Sep 26.
PMID: 23018816DERIVED
Related Links
Biospecimen
plasma and/or serum
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Shogo Takashiba, Professor
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Department of Pathiphysiology - Periodontal Science
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor and Chair
Study Record Dates
First Submitted
July 31, 2012
First Posted
August 7, 2012
Study Start
January 1, 2007
Primary Completion
November 1, 2009
Study Completion
March 1, 2010
Last Updated
August 7, 2012
Record last verified: 2012-08