NCT01654107

Brief Summary

The investigators propose to develop a theory-based smoking cessation intervention (called Persistence-targeted smoking cessation; PTSC). PTSC includes 8 weekly individual counseling sessions and use of nicotine lozenge for 12 weeks. The investigators will test the feasibility and preliminary efficacy of the intervention (i.e., cigarettes per day and prolonged abstinence).

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
58

participants targeted

Target at P50-P75 for phase_1

Timeline
Completed

Started Jul 2012

Typical duration for phase_1

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 1, 2012

Completed
18 days until next milestone

First Submitted

Initial submission to the registry

July 19, 2012

Completed
12 days until next milestone

First Posted

Study publicly available on registry

July 31, 2012

Completed
2.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2014

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2014

Completed
1 year until next milestone

Results Posted

Study results publicly available

September 16, 2015

Completed
Last Updated

August 21, 2017

Status Verified

July 1, 2017

Enrollment Period

2.2 years

First QC Date

July 19, 2012

Results QC Date

August 17, 2015

Last Update Submit

July 13, 2017

Conditions

Keywords

tobaccosmoking cessationnicotine dependence

Outcome Measures

Primary Outcomes (1)

  • 7-day Point Prevalence Abstinence

    3-months after the Quit Date

    3-months

Study Arms (2)

Persistence Targeted Smoking Cessation

EXPERIMENTAL

Persistence Targeted Smoking Cessation - 8 weeks counseling + 12 weeks nicotine lozenge

Behavioral: Persistence Targeted Smoking CessationDrug: Nicotine lozenge

Clearing The Air

ACTIVE COMPARATOR

Clearing the Air Smoking Cessation intervention - 8 weeks counseling + 12 weeks nicotine lozenge

Behavioral: Clearing The AirDrug: Nicotine lozenge

Interventions

8-weeks of smoking cessation counseling ("Persistence Targeted Smoking Cessation")

Also known as: PTSC
Persistence Targeted Smoking Cessation

8-weeks counseling + 12-weeks nicotine lozenge based on NCI protocol, Clearing The Air

Also known as: CTA
Clearing The Air

12-weeks 4mg nicotine lozenge

Clearing The AirPersistence Targeted Smoking Cessation

Eligibility Criteria

Age18 Years - 64 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Must be between 18 - 64 years old
  • Must smoke at least 10 cigarettes per day for past 6-months
  • Expired breath carbon monoxide (CO) \> 7
  • Must have a working cellular phone

You may not qualify if:

  • Must not be currently receiving tobacco dependence treatment counseling
  • Must not currently be taking varenicline, bupropion, or any nicotine preparations (gum, lozenge, patch, spray, inhaler)
  • Must have no contraindications to using nicotine lozenge

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Rutgers Robert Wood Johnson Medical School

New Brunswick, New Jersey, 08901, United States

Location

MeSH Terms

Conditions

Tobacco Use DisorderSmoking Cessation

Interventions

Tobacco Use Cessation Devices

Condition Hierarchy (Ancestors)

Substance-Related DisordersChemically-Induced DisordersMental DisordersHealth BehaviorBehavior

Intervention Hierarchy (Ancestors)

Therapeutics

Results Point of Contact

Title
Marc L. Steinberg, Ph.D.
Organization
Rutgers Robert Wood Johnson Medical School

Study Officials

  • Marc L Steinberg, Ph.D.

    Rutgers, The State University of New Jersey

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
interventional
Phase
phase 1
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor

Study Record Dates

First Submitted

July 19, 2012

First Posted

July 31, 2012

Study Start

July 1, 2012

Primary Completion

September 1, 2014

Study Completion

September 1, 2014

Last Updated

August 21, 2017

Results First Posted

September 16, 2015

Record last verified: 2017-07

Locations