NCT01648491

Brief Summary

Determine safety and effectiveness of the technique using autologous stem cells in the treatment of urinary incontinence in one male subject.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Oct 2011

Longer than P75 for not_applicable

Geographic Reach
1 country

2 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 2011

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

March 8, 2012

Completed
4 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2012

Completed
23 days until next milestone

First Posted

Study publicly available on registry

July 24, 2012

Completed
3.4 years until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2016

Completed
1 year until next milestone

Results Posted

Study results publicly available

January 10, 2017

Completed
Last Updated

January 10, 2017

Status Verified

November 1, 2016

Enrollment Period

9 months

First QC Date

March 8, 2012

Results QC Date

May 12, 2016

Last Update Submit

November 13, 2016

Conditions

Outcome Measures

Primary Outcomes (1)

  • Study-Related Adverse Events

    6 months

Secondary Outcomes (3)

  • Quality of Life (QOL) Described by the Patient's Response on the Patient Global Assessment of Severity (PGI-S) Questionnaire

    Baseline and 6 months

  • Quality of Life (QOL) Described by the Patient's Response on the Global Response Assessment (GRA)

    6 months

  • Quality of Life (QOL) Described by the Patient's Response on the Patient Global Impression of Improvement (PGI-I)

    6 months

Study Arms (1)

Stem Cell treatment

EXPERIMENTAL

Muscle Biopsy and Injection of autologous stem cells

Procedure: Muscle BiopsyBiological: Injection of autologous stem cells

Interventions

Muscle BiopsyPROCEDURE

Biopsy of thigh muscle to obtain stem cell core.

Stem Cell treatment

After autologous stem cells have multiplied over 6 weeks time they are injected into the subjects urethra.

Stem Cell treatment

Eligibility Criteria

Age78 Years - 82 Years
Sexmale
Healthy VolunteersNo
Age GroupsOlder Adult (65+)

You may qualify if:

  • urinary incontinence
  • failed urinary incontinence (UI) treatments

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Beaumont Hospital - Royal Oak

Royal Oak, Michigan, 48073, United States

Location

William Beaumont Hospital

Royal Oak, Michigan, 48073, United States

Location

MeSH Terms

Conditions

Urinary Incontinence, Stress

Condition Hierarchy (Ancestors)

Urinary IncontinenceUrination DisordersUrologic DiseasesFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesMale Urogenital DiseasesLower Urinary Tract SymptomsUrological ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Limitations and Caveats

This is a single patient compassionate use treatment.

Results Point of Contact

Title
Kenneth Peters MD
Organization
Beaumont Hospital - Royal Oak

Study Officials

  • Kenneth M Peters, MD

    Corewell Health East

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

March 8, 2012

First Posted

July 24, 2012

Study Start

October 1, 2011

Primary Completion

July 1, 2012

Study Completion

January 1, 2016

Last Updated

January 10, 2017

Results First Posted

January 10, 2017

Record last verified: 2016-11

Data Sharing

IPD Sharing
Will not share

Data will not be shared

Locations