Differentially Expressed Proteins in Sporadic Parathyroid Tumors

NCT01647503 | Unknown DMC

• 1 other identifier: parathyroid tumorigenesis
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Primary hyperparathyroidism (PHPT) is one of the common endocrine disorders. The major clinical symptoms involve stones, bones, abdominal groans and psychiatric moans. Increased parathyroid cell proliferation and decreased calcium-mediated control of the PTH secretion are characteristic findings. The most common cause of PHPT is adenoma followed by hyperplasia and carcinoma.The molecular mechanisms involved in parathyroid tumorigenesis are partially known. Few genes have been identified and their roles are under study. The genes which are under study by different groups are unable to give a definite direction towards the understanding of parathyroid tumorigenesis and the mechanism involved in overgrowth of parathyroid tissue. So identifying different proteins and their regulation pattern from adenomas to carcinomas will be the initial steps towards understanding the proteins involved in tumorigenesis of parathyroid tissues. By using proteomics approach one can generate protein level information. In this study, using a combined approach based on 2 D gel electrophoresis and mass spectrometry (MS), the investigators propose to study a comparative proteomics to examine the changes of protein profiles in parathyroid tumor tissues with normal and hyperplasic parathyroid tissues. This work plan will help us to understand differentially expressed proteins in patients with PHPT. This will help in understanding the disease and identifying better diagnostic and curative measures of the disease. The investigators are also planning to access nuclear morphometry changes in sporadic parathyroid tumors. It will help in establishing cellular and nuclear change pattern variations from normal to parathyroid tumors.

Conditions

Primary Hyperparathyroidism; Hypercalcemia

Keywords

parathyroid gland; primary hyperparathyroidism; proteins

Outcome Measures

Primary Outcomes (1)

• Differentially expressed proteins in parathyroid adenomas tissue samples

  At the end of three years of the study

Study Arms (2)

Tumor group

Parathyroid adenoma, hyperplasia and carcinoma

Normal

Normal parathyroid samples

Eligibility Criteria

• Age: 15 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients visiting the hospital for hypercalcemia, bone pain, renal problems and other symptoms related to primary hyperparathyroidim will be consider. Investigations and clinical symptoms will be confirmed for primary hyperpathyroidism. Finally if patient suggested for surgery then he will be included in the study

You may qualify if:

• PHPT patients with parathyroid adenoma, hyperplasia and carcinoma

You may not qualify if:

• Patients with family history, HPT-JT syndrome and familial isolated hyperparathyroidism

Sponsors & Collaborators

• Post Graduate Institute of Medical Education and Research, Chandigarh: lead

Study Sites (1)

PGIMER

Chandigarh, Uttarakhand, 1600012, India

RECRUITING

MeSH Terms

Conditions

Hyperparathyroidism, Primary; Hypercalcemia

Condition Hierarchy (Ancestors)

Hyperparathyroidism; Parathyroid Diseases; Endocrine System Diseases; Calcium Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Water-Electrolyte Imbalance

Study Officials

• Sanjay Kr Bhadada, DM

  Associate Professor, Department of Endocrinology, PGIMER Chandigarh India

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Sanjay Kr Bhadada, DM

CONTACT

bhadadask@rediffmail.com

Ashutosh Kr Arya, M Sc

CONTACT

aryan.hcu@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor, Dept of Endocrinology

Study Record Dates

• First Submitted: July 18, 2012
• First Posted: July 23, 2012
• Study Start: July 1, 2012
• Primary Completion: September 1, 2015
• Last Updated: April 16, 2014

Record last verified: 2014-04

Locations

IN (1)