Heritability of Fatty Liver as Measured by MRI: a Cross Sectional Study of Twins and Family Members
1 other identifier
observational
500
1 country
1
Brief Summary
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the United States. The cause of NAFLD is poorly defined but is thought to involve complex interactions of genetic and environmental factors. NAFLD is often associated with the traits of the metabolic syndrome including diabetes, high cholesterol or elevated blood pressure. Currently, there are no accurate noninvasive means of evaluating NAFLD and its more serious form which includes inflammation that may lead to severe scarring in the liver. The goal of this study is to evaluate shared genetic factors that underlie NAFLD and features of the metabolic syndrome as determined by blood work and radiographic studies in a cohort of twins and first degree relatives.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Aug 2011
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2011
CompletedFirst Submitted
Initial submission to the registry
July 16, 2012
CompletedFirst Posted
Study publicly available on registry
July 18, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2021
CompletedMay 6, 2021
May 1, 2021
10 years
July 16, 2012
May 3, 2021
Conditions
Eligibility Criteria
Twins and first degree relatives (sibling-sibling or offspring-parent).
You may qualify if:
- Subjects must be at least 18 years of age
- The subject is willing and able to complete all procedures and observations specified in the protocol
- The subject has been fully informed and has personally signed and dated the written Informed Consent/Assent and Health Insurance Portability and Accountability Act (HIPAA) provisions.
You may not qualify if:
- The subject is a female who is pregnant or nursing.
- Contraindications to MRI:
- The subject has any contraindication to MR imaging, such as patients with pacemakers, metallic cardiac valves, magnetic material such as surgical clips, implanted electronic infusion pumps or other conditions that would preclude proximity to a strong magnetic field.
- The subject has a history of extreme claustrophobia.
- The subject cannot fit inside the MR scanner cavity
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of California, San Diego
San Diego, California, 92103, United States
Related Links
Biospecimen
serum, plasma, urine, stool, DNA
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Rohit Loomba
UCSD
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- FAMILY BASED
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
July 16, 2012
First Posted
July 18, 2012
Study Start
August 1, 2011
Primary Completion
August 1, 2021
Study Completion
August 1, 2021
Last Updated
May 6, 2021
Record last verified: 2021-05