Electrophysiological Correlates of Emotional and Crossmodal Stimuli Processing Among Alcohol-dependent Participants

NCT01633905 | Completed

• 2 other identifiers: 2010_012010-A00595-34
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Alcohol-dependence is the most widespread addiction in Western countries and leads to a wide range of impairments at cerebral and cognitive levels. It has also been showed that alcohol-dependence is associated with emotional disturbances, particularly for the decoding of emotional facial expressions (EFE). In view of the crucial role played by EFE to develop and maintain satisfactory interpersonal relations, this emotional processing impairment may have deleterious consequences on alcohol-dependent patient's social well-being, and this deficit is thus of particular clinical interest. Nevertheless, this deficit has up to now been evaluated only by means of experiments using paradigms with low ecological value (i.e. presentation of EFE in isolation and in the central vision field), while in the real life, emotional stimuli are most frequently appearing together with other emotional stimulations (particularly voices) and in the peripheral vision field. Moreover, the cerebral correlates of this emotional deficit are still to be determined. The present study thus aims at exploring the Emotional Facial Expressions (EFE) decoding in alcoholism using a more ecological paradigm, based on peripheral presentation of emotional crossmodal stimuli (i.e. the simultaneous presentation of emotionally congruent face and voice). Main aim: Determining the electrophysiological characteristics (latencies and amplitudes) of the event-related components elicited among recently detoxified alcohol-dependent participants, while performing an emotion-detection task on crossmodal stimuli (voices and/or faces) presented centrally or peripherally, and comparing these characteristics with those obtained among paired healthy participants. Secondary objectives:

• Exploring the electrophysiological pattern modifications among alcohol-dependent participants for the emotional faces and voices decoding (unimodal conditions), using spatio-temporal analyses methods.
• Exploring the electrophysiological waves associated with peripheral crossmodal stimuli processing among healthy participants.
• Exploring the behavioral correlates (reaction times and accuracy) of the emotion-detection task among alcohol-dependent participants while processing peripheral stimuli.
• Exploring the psychopathological comorbidities among alcohol-dependent participants and their influence on the behavioral and electrophysiological results.

Conditions

Alcohol-dependence

Keywords

alcohol-dependence; event-related potentials; emotion; crossmodal; peripheral processing

Outcome Measures

Primary Outcomes (1)

• brain electrical responses amplitudes and latencies

  Differences in latencies, mainly the P3b wave, in milliseconds and differences in brain electrical responses amplitudes in millivolts, between the alcohol-dependent group and the healthy participants group.

  participants will be followed an average of 2 hours for the duration of experiment

Secondary Outcomes (3)

• reactions times

  participants will be followed an average of 2 hours for the duration of experiment

• behavioural and psychopathological measures

  participants will be followed an average of 2 hours for the duration of experiment

• percentage of correct answers

  participants will be followed an average of 2 hours for the duration of experiment

Study Arms (2)

alcohol-dependent patients

22 recently detoxified participants diagnosed as alcohol-dependant on the basis of DSM-IV criteria who will performed an emotion-detection task on unimodal (visual or auditory) or crossmodal (visuo-auditory) stimulations presented centrally or peripherally

control group

22 healthy controls without any psychiatric or neurological diagnosis who will performed an emotion-detection task on unimodal (visual or auditory) or crossmodal (visuo-auditory) stimulations presented centrally or peripherally

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

* 22 recently detoxified participants, diagnosed as alcohol-dependent on the basis of DSM-IV criteria, free of any alcohol consumption during the last 15 days, and without any other DSM-IV criteria * 22 healthy controls paired for gender, age and educational level with alcohol-dependent participants, without any alcohol consumption during the last three days and without any psychiatric or neurological diagnosis. All participants will be between 18 and 60 years of age, will be French-speaking and will present a normal or corrected-to-normal auditory and visual acuity.

You may qualify if:

• for alcohol-dependence group : alcohol-dependent subjects
• for control group : healthy volunteers without psychiatric
• for control group : healthy volunteers without neurological diagnosis

You may not qualify if:

• more than 60 years old and less than 18 years old,
• no French-speaking,
• not normal or not corrected-to-normal auditory acuity,
• not normal or not corrected-to-normal visual acuity

Sponsors & Collaborators

• University Hospital, Lille: lead

Study Sites (1)

University Hospital, Lille

Lille, 59037, France

Location

MeSH Terms

Conditions

Alcoholism

Condition Hierarchy (Ancestors)

Alcohol-Related Disorders; Substance-Related Disorders; Chemically-Induced Disorders; Mental Disorders

Study Officials

• Olivier COTTENCIN

  University Hospital, Lille

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 9, 2011
• First Posted: July 4, 2012
• Study Start: December 1, 2010
• Primary Completion: December 1, 2014
• Study Completion: December 1, 2014
• Last Updated: June 17, 2015

Record last verified: 2015-06

Locations

FR (1)