The Effect of Low Dose Aspirin in Increasing the Chance of Pregnancy
To Evaluate the Effect of Low Dose Aspirin in Increasing the Chance of Pregnancy in Frozen Embryo Transfer Cycles
1 other identifier
interventional
60
1 country
1
Brief Summary
It has been reported that low-dose aspirin and Heparin would lead to an increased Pregnancy rate in patients undergoing IVF-ET. Low-dose aspirin may improve uterine and ovarian perfusion and that aspirin might enhance endometrial receptivity and ovarian responsiveness as well, which could result in better implantation and pregnancy rates after IVF or ICSI treatment. This study assesses potential effects of low-dose aspirin (100 mg daily) on pregnancy rate following frozen embryo transfer.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for phase_3
Started May 2012
Typical duration for phase_3
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2012
CompletedFirst Submitted
Initial submission to the registry
May 14, 2012
CompletedFirst Posted
Study publicly available on registry
July 4, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2015
CompletedJanuary 18, 2017
March 1, 2012
4 months
May 14, 2012
January 15, 2017
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Pregnancy rate
evaluation the clinical pregnancy rate 6 weeks after emberyo transfering.
6 weeks
Secondary Outcomes (2)
Implantation rate
8 weeks
Miscarriage rate
12 weeks
Study Arms (2)
Asprin
EXPERIMENTALWith the onset of endometrial preparation and estrogen treatment, the study group will receive 100 mg of oral aspirin.
placebo
PLACEBO COMPARATORWith the onset of endometrial preparation and estrogen treatment, the control group will receive placebo
Interventions
Eligibility Criteria
You may qualify if:
- Patients with "long or antagonist" protocol
- Women who did not achieve a pregnancy following a fresh embryo transfer or women whom their embryos had not been transferred due to OHSS
- The women who had frozen embryos available for another transfer no contraindications for aspirin
You may not qualify if:
- The patients with history of recurrent abortion
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Royan Institutelead
Study Sites (1)
Royan Institute
Tehran, Iran
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Hamid Gourabi, PhD
Head of Royan institute
- STUDY DIRECTOR
Tahereh Madani, MD
Endocrinology and Female Infertility Department
- PRINCIPAL INVESTIGATOR
Firoozeh Ahmadi, MD
Reproductive Imaging Department
- PRINCIPAL INVESTIGATOR
Poopak Eftekhary, PhD
Embryology Department
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER GOV
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 14, 2012
First Posted
July 4, 2012
Study Start
May 1, 2012
Primary Completion
September 1, 2012
Study Completion
February 1, 2015
Last Updated
January 18, 2017
Record last verified: 2012-03