Colonic Stent and Tumor Cell Dissemination

NCT01628328 | Completed

• 1 other identifier: colonstent
• Study Type: observational
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study aims to examine the hypothesis of tumor cell dissemination after colonic stenting for obstructing colorectal cancer by measuring the level of plasma circulating tumor cell before and after the procedure of successful colonic stenting in patients.

Conditions

Colorectal Cancer

Keywords

colonic stenting; colorectal cancer obstruction; circulating tumor cell

Outcome Measures

Primary Outcomes (1)

• Changes of circulating tumor cell level before and after colonic stenting for patients with obstructive colorectal cancer

  The patients' peripheral blood will be collected before and on first 3 days after the procedure.

  Before and first 3 days after procedure

Study Arms (2)

Stenting

patient who received colonic stenting for obstructive colorectal cancer

Control

patients who had only colonoscopy without obstruction and without stenting

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study plan to recruit 20-30 patients in the stenting group and about 10-20 patients in the control groups. There is no previous study on this topic and hence, no information availabe for statistical analysis of sample size required to show a difference.

You may qualify if:

• Colonic stenting group
• Patients with obstructive colorectal cancer that requires colonic stenting as treatment
• Age \> 18 years and is able to give informed consent
• Informed consent for blood collection obtained
• Control group
• Patients with colorectal cancer who have colonoscopy without stenting
• Age \> 18 years and is able to give informed consent
• Informed consent for blood collection obtained

You may not qualify if:

• Patients who refuse or who is unable to give informed consent on blood taking for the study.

Sponsors & Collaborators

• The University of Hong Kong: lead

MeSH Terms

Conditions

Colorectal Neoplasms; Neoplastic Cells, Circulating

Condition Hierarchy (Ancestors)

Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Rectal Diseases; Neoplasm Metastasis; Neoplastic Processes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Jensen TC Poon, MS

  Department of Surgery, University of Hong Kong

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 21, 2012
• First Posted: June 26, 2012
• Study Start: July 1, 2010
• Primary Completion: December 1, 2011
• Study Completion: January 1, 2012
• Last Updated: June 26, 2012

Record last verified: 2012-06