Comparison of the Blister Fluid Components of Second Degree Burned Patients With the Blister Fluid Components Following Intralesional Cryosurgery of Keloid Scars - A Feasibility Study.
Sponsor study identifier
observational
20
1 country
1
Study Start
July 2012
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
June 2018
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Study Completion
July 2018
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It is well documented that following thermal burns injury the development of hypertrophic scars and keloid (HSK) ranges between 40 to 90%. on the other hand It is well documented that cryosurgery wounds generally heal with minimal tissue contraction, resulting in good cosmetic results and with minimal complications. The Aim of the study is To specify the burn and cryosurgery blister fluid for proteins, cytokines and cells and To compare between the above data regarding possible proteins, cytokines and cells, in regard to their possible effect on scarring and wound healing. Also to Identify those components which are present only in the cryosurgery blister and which might have an anti-scarring effect and to characterize them biochemically.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
July 2018
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
June 22, 2012
Actual (reported)June 26, 2012
Actual (reported)July 2012
Date type not reportedThis date has not been verified as actual or estimated.
June 2018
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
July 2018
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
comparison of inflamation cells and proteins (proteomic evaluation) between blisters caused by heat and blisters caused by cryo injury
the protein evaluation and comparison is achieved by the use of proteomic study which evaluate the quantity of about 700 different proteins in the fluid of the different blisters (heat blisters compared to "cryo" blisters). we also evaluate the differences in quntities between the inflamation cells in each sample.
at time of sampling.
blister fluids of second degree burns
blister fluids of cryosurgery wounds
patients with second degree burns patients status post cryosurgery treatment for keloid scars with post treatment blisters
Carmel Medical Center
Haifa, Haifa District, Israel
blister fluid of kryosurgery and second degree burns Following the results of the above study a further extension of the study is progressing in which the identification of the cell population in the blister fluid following intralesional cryosurgery of keloid scars is examined
yaron har-shai, Md
carmel medical center- ISRAEL
First Submitted
June 22, 2012
First Posted
June 26, 2012
Study Start
July 2012
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
June 2018
Estimated (date passed)Clinic Trial in Phase 1 Using Amniotic Membrane for the Skin Replacement in Big Wounds
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This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
July 2018
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
February 16, 2017
Record last verified: 2017-02
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