QST in Context With Conditioned Pain Modulation

NCT01618604 | Completed

• 1 other identifier: CPM2012
• Study Type: observational
• Target: 26
• Locations: 1 country
• Sites: 1

Brief Summary

Conditioned Pain Modulation (CPM) is a phenomenon which isn't examined enough. Many factors of influence such as gender, age and psyche are already known - but the duration of such effects, their reliability and the correlation between standardized Quantitative Sensory Testing (QST) and CPM is still unknown. In this study the investigators expect to find parameters in QST that correlate with the efficacy of Conditioned Pain Modulation. Knowing factors that indicate high or low potential CPM could help finding patients-at-risk and adapting their therapy.

Conditions

Healthy

Keywords

Conditioned Pain Modulation; Quantitative Sensory Testing; duration; correlation

Study Arms (1)

Healthy

26 healthy voluntary probands

Procedure: Quantitative Sensory Testing; Procedure: Conditioned Pain Modulation; Procedure: Repetition of four QST parameters

Interventions

Quantitative Sensory Testing PROCEDURE

following the standardized protocol of DFNS

Also known as: QST

Healthy

Conditioned Pain Modulation PROCEDURE

test stimulus by hot thermode conditioned stimulus by cold water bath

Also known as: CPM, DNIC, Diffuse Noxious Inhibitory Controls

Healthy

Repetition of four QST parameters PROCEDURE

* warm detection threshold (WDT) * cold detection threshold (CDT) * mechanical detection threshold (MDT) * mechanical pain threshold (MPT)

Also known as: WDT, CDT, MDT, MPT, Quantitative Sensory Testing

Healthy

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Healthy voluntary probands

You may qualify if:

• healthy probands \>18 years
• right-handedness
• informed consent
• no chronic pain
• no drugs (but oral contraceptives)
• no neurological diseases
• no psychiatric diseases

You may not qualify if:

• no informed consent
• language deficits
• left-handedness
• not enough pain intensity by thermode or cold water bath
• psychiatric disease, neurological diseases other chronic disease
• chronic pain syndromes
• pregnancy or lactation
• permanent drug use, drug use in the last 14 days

Sponsors & Collaborators

• Ruhr University of Bochum: lead

Study Sites (1)

Bergmannsheil, department for pain management

Bochum, North Rhine-Westphalia, 44789, Germany

Location

Related Publications (1)

• Gehling J, Mainka T, Vollert J, Pogatzki-Zahn EM, Maier C, Enax-Krumova EK. Short-term test-retest-reliability of conditioned pain modulation using the cold-heat-pain method in healthy subjects and its correlation to parameters of standardized quantitative sensory testing. BMC Neurol. 2016 Aug 5;16:125. doi: 10.1186/s12883-016-0650-z.

  PMID: 27495743 DERIVED

Study Officials

• Christoph Maier, Prof. Dr. med

  University hospital Bergmannsheil department of pain management

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of the Dep. of Pain Management

Study Record Dates

• First Submitted: June 11, 2012
• First Posted: June 13, 2012
• Study Start: May 1, 2012
• Primary Completion: December 1, 2012
• Study Completion: December 1, 2012
• Last Updated: January 3, 2013

Record last verified: 2012-12

Locations

DE (1)