The Rubber Hand Illusion (RHI) in Patients With CRPS

NCT01618578 | Completed

• 1 other identifier: RHI2010
• Study Type: observational
• Target: 69
• Locations: 1 country
• Sites: 1

Brief Summary

The present study investigates by means of the rubber hand illusion body image stability and sense of body ownership in patients with CRPS of the upper limb compared to patients with unilateral pain of origin other than CRPS and age and sex-matched healthy subjects.

Conditions

CRPS; Unilateral Limb Pain of Origin Other Than CRPS

Keywords

rubber hand illusion; CRPS; body image; body ownership

Outcome Measures

Primary Outcomes (1)

• subjective illusion strength by a validated questionnaire

  The illusion strength was measured subjectively by a validated questionnaire on a 7- point Likert scale,ranging from 0 (= disagree strongly) to 7 (= agree strongly). The questionnaire encompassed five slightly modified items of the German-translated questionnaire by Ocklenburg et al.(2011), following Botvinick \& Cohen (1998).In the experimental conditions the questionnaire was additionally augmented by three further statements regarding the perception of the needle threat.

  1 hour

Secondary Outcomes (2)

• objectified illusion strength by measure of skin conductance response (SCR)

  1 hour

• Measurement of influences of the illusion strength

  half an hour

Study Arms (3)

Patients with CRPS

24 patients with CRPS of the upper limb type 1 were included into the study.

Procedure: rubber hand illusion

Patients with unilateral upper limb pain

21 patients with unilateral upper limb pain served as controls.

Procedure: rubber hand illusion

healthy subjects

24 healthy subjects were age- and sex matched to patients with CRPS.

Procedure: rubber hand illusion

Interventions

rubber hand illusion PROCEDURE

There were three consecutive trials of the RHI: 1. one control trial: asynchronous condition (3 Min.) 2. two experimental trials (conducted on both hands):synchronous condition (3 Min.),additionally watching the prosthesis being threatened (20 sec.)

Patients with CRPS; Patients with unilateral upper limb pain; healthy subjects

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study sample consists of three groups: 1. Patients with CRPS of the upper limb type 1 ( n=24) 2. Patients with unilateral pain of the upper limb origin other than CRPS (n=21) 3. Healthy subjects, age and sex-matched to patients with CRPS Patients with unilateral pain of the upper limb of origin other than CRPS serve as controls. Recruitment for all CRPS and the majority of patients in the control group took place in the pain clinic of the Bergmannsheil University Hospital in Bochum. The remaining patients were recruited from the Neurological respectively Surgical department of the Bergmannsheil University Hospital.

You may qualify if:

• every participant:
• aged \> 18 years
• written informed consent
• free to withdraw participation at any time
• adequate understanding of the german language
• Patients with CRPS:
• patients with CRPS type 1 of the upper limb
• clinical symptoms were diagnosed on the basis of the recently modified diagnostic research criteria (Harden, Bruehl et al., 2007)
• proved by typical enhancement in the late phase of the 99m-technetium-triple-phase bone skeleton scintigraphy (Wüppenhorst, Maier et al., 2010)
• Patients with unilateral pain of the upper limb:
• unilateral pain
• pain of origin other than CRPS
• Healthy subjects:
• age and sex matched to patients with CRPS
• checked by the DFNS IMI questionnaire

You may not qualify if:

• every participant:
• inadequate understanding of the german language
• missing informed consent
• diabetes mellitus
• Patients with CRPS:
• CRPS Type 2

Sponsors & Collaborators

• Ruhr University of Bochum: lead

Study Sites (1)

Pain clinic of the Bergmannsheil University Hospital

Bochum, 44789, Germany

Location

Study Officials

• Christoph Maier, Prof. Dr.

  Head of the pain clinic of the Bergmannsheil University Hospital

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof. Dr. med. (Head of the pain clinic of the Bergmannsheil University Hospital)

Study Record Dates

• First Submitted: June 11, 2012
• First Posted: June 13, 2012
• Study Start: May 1, 2010
• Primary Completion: November 1, 2011
• Study Completion: November 1, 2011
• Last Updated: June 26, 2012

Record last verified: 2012-06

Locations

DE (1)