Urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) in Invasive Cardiology
Is Urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) the "Renal Troponin" in Invasive Cardiology?
1 other identifier
observational
244
1 country
1
Brief Summary
Diagnosis of acute kidney injury (AKI) relies on a late marker, namely serum creatinine (SCr). New biomarkers are considered for early and sensitive detection of CIN. In particular, uNGAL has been used for early detection of AKI in the emergency department, after cardiopulmonary bypass or following CM administration. This study will be conducted to assess the possible value of urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) as an early detector of contrast-induced nephropathy (CIN) in a large sized cohort of patients undergoing percutaneous coronary procedures (PCP) and whether or not uNGAL correlates with the volume of contrast medium (CM) used.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Nov 2011
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 1, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2012
CompletedFirst Submitted
Initial submission to the registry
May 30, 2012
CompletedFirst Posted
Study publicly available on registry
June 5, 2012
CompletedMay 28, 2014
May 1, 2014
3 months
May 30, 2012
May 27, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
to assess the value of uNGAL measurement 4 to 6 hours after PCP as a possible early detector of CIN
cf title
4-6 hours after PCP
Secondary Outcomes (1)
to study the relationship between the volume of contrast medium used for PCP and the uNGAL levels measured 4 to 6 hours thereafter
4-6 hours after PCP
Study Arms (1)
consecutive, PCP patients
All patients requiring percutaneous coronary procedures, such as coronary angiography or intervention
Eligibility Criteria
all consecutive patients
You may not qualify if:
- dialysis-dependent chronic kidney disease
- lack of written consent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Department of Cardiology
Fribourg, Canton of Fribourg, 1708, Switzerland
Related Publications (1)
Perrin T, Descombes E, Magnin JL, Gachet M, Hemett OM, Hayoz D, Stolt V, Baeriswyl G, Stauffer JC, Goy JJ, Togni M, Cook S. Urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) and contrast-induced acute kidney injury after coronary angiogram. Swiss Med Wkly. 2013 Aug 27;143:w13853. doi: 10.4414/smw.2013.13853. eCollection 2013.
PMID: 23986375RESULT
Biospecimen
urinary samples
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Stephane Cook, MD
University Fribourg
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Ms
Study Record Dates
First Submitted
May 30, 2012
First Posted
June 5, 2012
Study Start
November 1, 2011
Primary Completion
February 1, 2012
Study Completion
February 1, 2012
Last Updated
May 28, 2014
Record last verified: 2014-05