NCT01608945

Brief Summary

The major drawback of hepatic pedicle clamping is ischaemia-reperfusion injury with impairment of liver function. Perioperative steroid administration has been advocated to reduce liver damage. The aim of this prospective, randomized study was to determine whether steroid administration can reduce liver injury and impact the prognosis

Trial Health

20
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial recruitment is currently suspended
Enrollment
60

participants targeted

Target at P25-P50 for all trials

Status
suspended

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2008

Completed
4.2 years until next milestone

First Submitted

Initial submission to the registry

May 29, 2012

Completed
2 days until next milestone

First Posted

Study publicly available on registry

May 31, 2012

Completed
Last Updated

May 31, 2012

Status Verified

May 1, 2012

First QC Date

May 29, 2012

Last Update Submit

May 30, 2012

Conditions

Some Studies Shows That the Steroid Can Reduce the Injury of the I/R of the Liver

Keywords

steroidliver functionprognosis

Outcome Measures

Primary Outcomes (1)

  • liver function

    six months

Study Arms (1)

steroid,liver function I/R

Drug: Hydrocortisone sodium succinate

Interventions

Hydrocortisone sodium succinateDRUG

100mg/day

steroid,liver function I/R

Eligibility Criteria

Age18 Years - 70 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

60

You may qualify if:

  • years old
  • diametre of the mass\>3cm.
  • hcc

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Interventions

Hydrocortisone

Intervention Hierarchy (Ancestors)

PregnenedionesPregnenesPregnanesSteroidsFused-Ring CompoundsPolycyclic Compounds11-HydroxycorticosteroidsHydroxycorticosteroidsAdrenal Cortex HormonesHormonesHormones, Hormone Substitutes, and Hormone Antagonists17-Hydroxycorticosteroids

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
hepatic department

Study Record Dates

First Submitted

May 29, 2012

First Posted

May 31, 2012

Study Start

April 1, 2008

Last Updated

May 31, 2012

Record last verified: 2012-05