Exercise, Glucose Kinetics, and the Incretin Effect

NCT01607931 | Completed

• 1 other identifier: EFSD-2012
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

Human volunteers will be stratified by oral glucose tolerance status: normal glucose tolerant, impaired glucose tolerant, and type 2 diabetic. All subjects will undergo 4 experimental trials: \[1\] an oral glucose tolerance test (OGTT) combined with infused and ingested stable isotopes of glucose to assess glucose kinetics. \[2\] a 1 hour bout of cycling exercise at 50% of maximum power output, immediately followed by the same OGTT combined with stable isotope glucose tracers used in trial 1. \[3\] an isoglycemic clamp to match the plasma glucose profile measured in trial 1. \[4\] a 1 hour bout of cycling exercise at 50% of maximum power output, immediately followed by an isoglycemic clamp to match the plasma glucose profile measured in trial 2. Exercise-induced changes in oral glucose tolerance, glucose kinetics, insulin and glucagon secretion, and the incretin effect will be examined. The exercise responses will be compared between the subjects groups of different glucose tolerance status.

Conditions

Type 2 Diabetes

Keywords

Exercise; Physical activity; Type 2 diabetes; Obesity; Incretin effect; GLP-1; GIP; Insulin secretion; Glucagon; Beta-cell function; Disposition Index

Outcome Measures

Primary Outcomes (2)

• Glucose tolerance

  Plasma glucose will be measured at 10 minute intervals during the OGTT (3 hours) immediately following the period of rest or exercise

• Incretin effect

  Plasma insulin and C-peptide will be measured at 10 minute intervals during the OGTT (3 hours) and isoglycemic clamp (3 hours) immediately following the period of rest or exercise

Study Arms (2)

Resting Trial

NO INTERVENTION

a 1 hour period of rest immediately prior to OGTT or isoglycemic clamp

Exercise Trial

EXPERIMENTAL

a 1 hour cycling exercise bout immediately prior to the OGTT or isoglycemic clamp

Behavioral: Exercise

Interventions

Exercise BEHAVIORAL

1 hour of cycling at 50% of maximum power output

Exercise Trial

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• age 18-60 years
• BMI 18-35 kg/m2

You may not qualify if:

• insulin dependency
• pregnancy
• presence or history of chronic cardiovascular, pulmonary, hepatic, renal, or hematological disease, or cancer
• contraindication to physical activity as assessed by ECG

Sponsors & Collaborators

• Rigshospitalet, Denmark: lead

Study Sites (1)

Rigshospitalet

Copenhagen, Denmark

Location

MeSH Terms

Conditions

Diabetes Mellitus, Type 2; Motor Activity; Obesity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Behavior; Overweight; Overnutrition; Nutrition Disorders; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Senior Researcher

Study Record Dates

• First Submitted: May 23, 2012
• First Posted: May 30, 2012
• Study Start: January 1, 2013
• Primary Completion: April 1, 2016
• Study Completion: July 1, 2016
• Last Updated: August 12, 2016

Record last verified: 2016-08

Locations

DK (1)