Colorectal Polypectomy Upon Insertion And Withdrawal Or Upon Withdrawal Only?
1 other identifier
interventional
400
1 country
1
Brief Summary
The investigators aim to assess the procedure time and miss rate of polyps when performing polypectomy in the colon on the way up\* and down\*\* or only on the way down\*\*. (\* advancing the scope to the cecum, \*\* pulling back the scope after intubation of the cecum). Our hypothesis is that using the strategy to remove all visible polyps firstly on the way up and secondly on the way down is less time consuming and misses less polyps as with the strategy to remove polyps only on the way down.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Apr 2004
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2004
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2007
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2007
CompletedFirst Submitted
Initial submission to the registry
May 24, 2012
CompletedFirst Posted
Study publicly available on registry
May 30, 2012
CompletedJune 19, 2012
June 1, 2012
2.9 years
May 24, 2012
June 18, 2012
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Polyp detection
2004 - 2007
Study Arms (2)
Polyp removal upon insertion and withdrawal
ACTIVE COMPARATORPolyp removal upon withdrawal only
NO INTERVENTIONInterventions
Endoscopic procedures: All polypectomies in the study groups were performed using the same techniques as in the standard care of non-study patients, using snare loops, hot biopsy forceps, with and without submucosal injection of saline/epinephrine. Polyps larger than 3 mm were removed by snare, polyps smaller than 4 mm were removed by cold biopsy. There were no differences upon insertion or withdrawal. The endoscopist removed all visible polyps instantly regardless whether advancing the instrument to the cecum or pulling back.
Endoscopic procedures: All polypectomies in the study groups were performed using the same techniques as in the standard care of non-study patients, using snare loops, hot biopsy forceps, with and without submucosal injection of saline/epinephrine. Polyps larger than 3 mm were removed by snare, polyps smaller than 4 mm were removed by cold biopsy. There were no differences upon insertion or withdrawal. The endoscopist advanced the endoscope to the cecum without removing polyps. Upon withdrawal, all visible polyps were removed successively by standard techniques.
Eligibility Criteria
You may qualify if:
- Need for a complete colonoscopy
- years of age and older
You may not qualify if:
- Need for urgent colonoscopy due to bleeding
- High likelihood of colonic stenosis or severe inflammation
- Known inflammatory bowel disease (IBD)
- Known familiarity adenomatous polyposis (FAP)
- Contraindications for polypectomy such as coagulopathy, use of anti-clotting medication (anticoagulation, aspirin, NSAIDs)
- Missing signed consent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Zürich
Zurich, Canton of Zurich, 8091, Switzerland
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Stephan M. Wildi, MD
University of Zurich
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, OUTCOMES ASSESSOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Stephan M. Wildi, Principle Investigator
Study Record Dates
First Submitted
May 24, 2012
First Posted
May 30, 2012
Study Start
April 1, 2004
Primary Completion
March 1, 2007
Study Completion
April 1, 2007
Last Updated
June 19, 2012
Record last verified: 2012-06