Islet Transplant for Type 1 or Surgical Diabetes

You may not qualify if:

• HbA1c \>10%.
• Untreated proliferative diabetic retinopathy.
• Uncontrolled Hypertension (SBP\>160 or DBP\>100)
• For female participants: Positive pregnancy test, presently breast-feeding, or unwillingness to use effective contraceptive measures for the duration of the study.
• Active infection including hepatitis B, hepatitis C, HIV, or TB as determined by a positive skin test or clinical presentation, or under treatment for suspected TB.
• Any history of malignancy except for completely resected squamous or basal cell carcinoma of the skin.
• Receiving treatment for a medical condition requiring chronic use of systemic steroids, except for use of prednisone \<5 mg per day for kidney transplant recipients or physiologic hydrocortisone replacement.
• Persistent elevation of liver function tests at the time of study entry. Persistent SGOT (AST), SGPT (ALT), Alk Phos or total bilirubin, with values \>1.5 times normal upper limits will exclude a patient.
• Severe co-existing cardiac disease, characterized by any one of these conditions:
• recent myocardial infarction (within past 6 months).
• evidence of ischemia on functional cardiac exam within the last year.
• left ventricular ejection fraction \<30%.
• If diabetes is secondary to total pancreatectomy, participants will be considered only if \>1 year out from surgery, medically stable, without severe issues with bowel function or pain management that may interfere with safe completion of the trial.
• History of alcoholism
• Any medical condition that, in the opinion of the investigator, will interfere with the safe completion of the trial.