ProspEctive First Evaluation in Chest Pain Trial
PERFECT
ProspEctive Randomized First Evaluation in Chest Pain Trial
1 other identifier
interventional
411
1 country
1
Brief Summary
The purpose of this study is to determine the best initial test in patients admitted to the hospital complaining of chest pain.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Sep 2011
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2011
CompletedFirst Submitted
Initial submission to the registry
May 17, 2012
CompletedFirst Posted
Study publicly available on registry
May 24, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2015
CompletedMarch 8, 2016
March 1, 2016
2.3 years
May 17, 2012
March 7, 2016
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
Time to discharge
Initial hospitalization
Change in medical regimen
Initial hospitalization
Downstream cardiovascular testing and hospitalization
2 years
Secondary Outcomes (3)
All-cause mortality
7 days, 30 days, 6, 12, and 24 months.
Cardiovascular mortality
7 days, 30 days, 6, 12, and 24 months.
Non-fatal myocardial infarction
7 days, 30 days, 6, 12, and 24 months.
Study Arms (2)
Coronary CT Angiography
ACTIVE COMPARATORPatient admitted with chest pain is randomized to CCTA for assessment.
Stress Test
ACTIVE COMPARATORPatients admitted with chest pain are randomized to a stress test (stress SPECT or Echocardiography) for assessment.
Interventions
Eligibility Criteria
You may qualify if:
- Patients with chest pain or SOB admitted for rule out acute coronary syndrome
- Age ≥45 years
- EKG non-diagnostic for acute coronary syndrome
- At least 1 set of negative troponin I
You may not qualify if:
- Patient with ST elevation myocardial infarction.
- Patients with non-ST elevation myocardial infarction.
- Patients with known CAD.
- Patients with serum creatinine \> 1.5.
- Atrial fibrillation or marked irregular heart rhythm.
- Patients in whom heart rate cannot be controlled.
- Patient with allergies to iodinated contrast agents.
- Pregnant women
- Patients unable to give informed consent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
St. Luke's and Roosevelt Hospitals
New York, New York, 10025, United States
Related Publications (1)
Uretsky S, Argulian E, Supariwala A, Agarwal SK, El-Hayek G, Chavez P, Awan H, Jagarlamudi A, Puppala SP, Cohen R, Rozanski A. Comparative effectiveness of coronary CT angiography vs stress cardiac imaging in patients following hospital admission for chest pain work-up: The Prospective First Evaluation in Chest Pain (PERFECT) Trial. J Nucl Cardiol. 2017 Aug;24(4):1267-1278. doi: 10.1007/s12350-015-0354-6. Epub 2016 Apr 5.
PMID: 27048306DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Seth Uretsky, MD
St. Luke's and Roosevelt Hospital Centers
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- DIAGNOSTIC
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 17, 2012
First Posted
May 24, 2012
Study Start
September 1, 2011
Primary Completion
December 1, 2013
Study Completion
December 1, 2015
Last Updated
March 8, 2016
Record last verified: 2016-03