Screening for Thoracic Aortic Aneurysm Among a Cohort of Patients With a Degenerative Abdominal Aortic Aneurysm

NCT01599533 | Completed

• 2 other identifiers: 2011-A00042-412012-01
• Study Type: interventional
• Target: 345
• Locations: 1 country
• Sites: 1

Brief Summary

Many publications deal with the natural history of aortic aneurysms in literature. Except for connective tissue disorders as Marfan or Loeys-Dietz syndrome, aortic aneurysms are a complex multifactorial disease with genetic and environmental risk factors. Susceptibility loci identified in thoracic aortic aneurysms (TAA) and abdominal aortic aneurysms (AAA) do not overlap, suggesting that different genetic risk factors contribute to these two forms of aneuryms. With a higher prevalence correlated to ageing (5%), AAA is usually presented as the degenerative form of the disease. However, a recent epidemiologic study by Olsson et al. has revealed an increasing incidence of thoracic aortic disease among older individuals (70+/-12 years) with 60% of aneurysmal rupture or dissection at diagnosis, and a 1.7 :1 male-to-female ratio compared to 6:1 in AAA. From this current knowledge arises the concept of diffuse or plurisegmental degenerative aneurysmal aortic disease, poorly explored so far. As regards to the prevention policy, there is a consensus statement in which ultrasonography screening for AAA is recommended for all individuals aged \> 60 years (particularly in men who have ever smoked) and for those aged \> 50 years with family history of AAA. Nevertheless, screening for a concomittant thoracic location of the disease (except thoracoabdominal aneurysm) is not yet required, whereas it could change the prognosis of the patients and influence their management.

Conditions

Abdominal Aortic Aneurysms

Outcome Measures

Primary Outcomes (1)

• BLOOD SAMPLES

  to determine the prevalence thoracic aortic aneurysms (TAA) and abdominal aortic aneurysms (AAA)

  3 YEARS

Secondary Outcomes (2)

• ANGIOSCAN

  3 YEARS

• CARDIAC STATEMENT

  3 YEARS

Study Arms (1)

abdominal aortic aneurysms

OTHER

Other: blood samples

Interventions

blood samples OTHER

abdominal aortic aneurysms

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Subject sent in hospitalization or in consultation of surgery vascular for coverage of the first one anévrysme of the sub-renal abdominal aorta degenerative, without anomaly associated by the coeliac aorta, and by the upper diameter in 40mm (according to the criteria of measure recommended for the analysis in echography doppler or in angioscanner).
• subject not presenting contraindication to the realization of the diagnostic examination by aortic angioscanner
• Subject having signed a consent.

You may not qualify if:

• Subject under age 18
• pregnant Woman
• Subject received in the phase aigue of a break or a fissuring of an AAA under renal
• Subject already operated for a thoracic or abdominal aortic anévrysme
• Subject presenting at least one of the following pathologies:
• heart disorder valvulaire aortic: aortic incapacity of rank superior to 2, tight aortic stenosis, prosthesis valvulaire aortic
• context of bicuspidie station wagon diagnosed on at least 2 parents of the first degree
• of a not degenerative aortopathie anévrysmale bound(connected) in bicuspidie aortic, or: A dissection of type(chap) A or of type(chap) B
• Of a degenerative aortopathie of type anévrysme thoracoabdominal (in particular, affected by the coeliac aorta, defined by the segment enter the diaphragmatique crossing and the renal arteries)

Sponsors & Collaborators

• Assistance Publique Hopitaux De Marseille: lead

Study Sites (1)

Assistance Publique Hopitaux de Marseille

Marseille, 13354, France

Location

MeSH Terms

Conditions

Aortic Aneurysm, Abdominal

Interventions

Blood Specimen Collection

Condition Hierarchy (Ancestors)

Aortic Aneurysm; Aneurysm; Vascular Diseases; Cardiovascular Diseases; Aortic Diseases

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Study Officials

• BERNARD BELAIGUES

  Assistance Publique hôpitaux de Marseille

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 10, 2012
• First Posted: May 16, 2012
• Study Start: June 1, 2012
• Primary Completion: July 1, 2017
• Study Completion: July 1, 2018
• Last Updated: December 2, 2019

Record last verified: 2019-10

Locations

FR (1)