Oxytocin, Couple Interaction and Wound Healing
1 other identifier
interventional
160
1 country
1
Brief Summary
effects of intranasal oxytocin and couple interaction on wound healing.
- Trial with medicinal product
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_1 healthy-volunteers
Started Oct 2011
Longer than P75 for phase_1 healthy-volunteers
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2011
CompletedFirst Submitted
Initial submission to the registry
May 7, 2012
CompletedFirst Posted
Study publicly available on registry
May 9, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
October 1, 2013
CompletedFebruary 25, 2014
February 1, 2014
2 years
May 7, 2012
February 24, 2014
Conditions
Outcome Measures
Primary Outcomes (1)
wound size
wound healing process within seven days after wounding
seven days
Study Arms (2)
nasal spray
ACTIVE COMPARATORPlacebo
PLACEBO COMPARATORInterventions
two-times daily self-administration of nasal spray containing active substance (oxytocin) during five days after wounding.
two-times daily self-administration of nasal spray containing placebo during five days after wounding.
Eligibility Criteria
You may qualify if:
- healthy heterosexual couples
- in a stable relationship since \> 1 year
You may not qualify if:
- breast feeding
- heavy smoking (\> 5 cigarettes/d)
- extensive skin disease
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Zurichlead
- Swiss National Science Foundationcollaborator
Study Sites (1)
University Hospital Zurich, Dept. of Dermatology
Zurich, 8091, Switzerland
Related Publications (3)
Schneider E, Hernandez C, Brock R, Eckstein M, Bodenmann G, Heinrichs M, Ehlert U, Lauchli S, Ditzen B. Intranasal Oxytocin and Physical Intimacy for Dermatological Wound Healing and Neuroendocrine Stress: A Randomized Clinical Trial. JAMA Psychiatry. 2025 Nov 12:e253705. doi: 10.1001/jamapsychiatry.2025.3705. Online ahead of print.
PMID: 41222549DERIVEDAguilar-Raab C, Stoffel M, Fischer M, Eckstein M, Bodenmann G, Heinrichs M, Ehlert U, Ditzen B. Minimal couple intervention to improve psychobiological stress resilience. Br J Health Psychol. 2025 May;30(2):e12799. doi: 10.1111/bjhp.12799.
PMID: 40356464DERIVEDDoerr JM, Klaus K, Troxel W, Nater UM, Bodenmann G, Heinrichs M, Ehlert U, Ditzen B. The Effect of Intranasal Oxytocin on the Association Between Couple Interaction and Sleep: A Placebo-Controlled Study. Psychosom Med. 2022 Jul-Aug 01;84(6):727-737. doi: 10.1097/PSY.0000000000001091. Epub 2022 Apr 27.
PMID: 35472193DERIVED
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
01 Studienregister MasterAdmins
UniversitaetsSpital Zuerich
- PRINCIPAL INVESTIGATOR
Severin Laeuchli, MD
University Hospital Zurich, Division of Dermatology
Study Design
- Study Type
- interventional
- Phase
- phase 1
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 7, 2012
First Posted
May 9, 2012
Study Start
October 1, 2011
Primary Completion
October 1, 2013
Study Completion
October 1, 2013
Last Updated
February 25, 2014
Record last verified: 2014-02