Hereditary Haemorrhagic Telangiectasia Flight Safety Study

NCT01590121 | Completed Results

• 1 other identifier: CLS/20
• Study Type: observational
• Target: 156
• Locations: 1 country
• Sites: 1

Brief Summary

Hereditary Haemorrhagic Telangiectasia (HHT) is a condition in which sufferers have abnormal blood vessels which makes them more likely to bleed than other people, particularly in the lungs, which results in low blood oxygen levels. Flying may make this worse and cause problems. The investigators want to know if there are an increased number of problems on flights compared to on land. The investigators currently do not have any evidence based guidelines on air travel to best advice people who suffer with HHT. The investigators would therefore like to ask individuals who have HHT about their experience on a flight, using a postal questionnaire.

Conditions

Hereditary Haemorrhagic Telangiectasia

Keywords

Previous flight by aeroplane

Outcome Measures

Primary Outcomes (1)

• HHT Patients Who by the Questionnaire Did or Did Not Self Report a Medical Complication During Flight

  Of all patients who were sent the questionnaire, this comparison was limited to those who had taken a flight, either long haul or short haul. Participants were compared as to whether they did or did not suffer a flight complication.

  Patient were asked to report all flights taken up until questionnaire completion aged 18-90 (mean 55)ys. 145 HHT-affected respondents had flown for 18,943 hours over 3,950 flights.

Study Arms (1)

Pateints with hereditary haemorrhagic telangiectasia

Other: Aeroplane flight in the past- no active intervention for study; Other: Questionnaire

Interventions

Aeroplane flight in the past- no active intervention for study OTHER

Aeroplane flight(s) previously taken by study participants

Pateints with hereditary haemorrhagic telangiectasia

Questionnaire OTHER

Flight by aeroplane (previous)

Pateints with hereditary haemorrhagic telangiectasia

Eligibility Criteria

• Age: 16 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

HHT patients previously assesses at Hammersmith Hospital, England

You may qualify if:

• HHT

You may not qualify if:

• Unable to provide informed consent

Sponsors & Collaborators

• Imperial College London: lead

Study Sites (1)

HammersmithHospital, Imperial College Healthcare NHS Trust

London, W12 0NN, United Kingdom

Location

Related Publications (1)

• Mason CG, Shovlin CL. Flight-related complications are infrequent in patients with hereditary haemorrhagic telangiectasia/pulmonary arteriovenous malformations, despite low oxygen saturations and anaemia. Thorax. 2012 Jan;67(1):80-1. doi: 10.1136/thoraxjnl-2011-201027. Epub 2011 Sep 26.

  PMID: 21953065 RESULT

MeSH Terms

Conditions

Telangiectasia, Hereditary Hemorrhagic

Interventions

Surveys and Questionnaires

Condition Hierarchy (Ancestors)

Hemostatic Disorders; Vascular Diseases; Cardiovascular Diseases; Telangiectasis; Hemorrhagic Disorders; Hematologic Diseases; Hemic and Lymphatic Diseases; Vascular Malformations; Cardiovascular Abnormalities; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Results Point of Contact

• Title: Dr. Claire Shovlin, Principal Investigator
• Organization: Imperial College London

c.shovlin@imperial.ac.uk

+44 208 383 1178

Study Officials

• Claire L Shovlin, PhD MA MB BChir FRCP

  Imperial College London

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 30, 2012
• First Posted: May 2, 2012
• Study Start: January 1, 2010
• Primary Completion: October 1, 2011
• Study Completion: October 1, 2011
• Last Updated: November 12, 2024
• Results First Posted: November 12, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)