NCT01589965

Brief Summary

The HIV/AIDS epidemic is a major concern in many countries. The epidemic is especially acute in Lesotho where roughly one quarter of the population is infected by HIV/AIDS. In Lesotho, and elsewhere, new innovative approaches to induce safer sexual behavior have been desperately called for, particularly in view of the limited impact that existing prevention schemes have had on the trajectory of the HIV/AIDS epidemic. One of the key questions is to understand why individuals get involved in short-term risky sexual behavior when the potential long-term cost of becoming HIV infected is so high? A follow-up question is what replicable and feasible interventions can affect this trade-off between short and long run returns? The primary aim of this study is to evaluate whether the use of short-term financial incentives can affect this trade-off, thereby influencing young individuals' decisions with respect to sexual and reproductive health behavior, and thus in the end reduce HIV incidence rates. The investigators will study this question using a sample of population attending served by New Start Voluntary Counseling and Testing (VCT) sites that a local NGO, Population Service International (PSI), has already implemented in Lesotho. The investigators propose to conduct a randomized controlled trial to test whether adding a financial incentive to remain STI-negative in the form of a lottery can promote safer sexual activity. The lotteries will work as follows: if the individual is tested negative on a set of curable STIs, she will get a lottery ticket with the chance to win a "big" prize. If she is tested positive, she will receive free treatment, but no lottery ticket. If an individual who tested positive is cured, she can come back in the lottery system and get a later chance to win the lottery ticket if she remains STI-negative. The outcome will be to measure the impact of financial incentives on HIV incidence after two years. The results of this research project will be disseminated through academic and non-academic conferences, workshops, publications in academic journals, and also in policy journals with the aim to reach out to policy makers outside the research community.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
5,000

participants targeted

Target at P75+ for early_phase_1

Timeline
Completed

Started Feb 2010

Typical duration for early_phase_1

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 1, 2010

Completed
Same day until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2010

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

April 19, 2010

Completed
2 years until next milestone

First Posted

Study publicly available on registry

May 2, 2012

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2012

Completed
Last Updated

May 2, 2012

Status Verified

May 1, 2012

Enrollment Period

Same day

First QC Date

April 19, 2010

Last Update Submit

May 1, 2012

Conditions

Keywords

HIV/AIDSSTIsLottery

Outcome Measures

Primary Outcomes (1)

  • HIV prevalence

    2 years

Secondary Outcomes (1)

  • STI prevalence (Chlamydia, Syphilis, Trichomoniasis)

    2 years

Study Arms (3)

Treatment group: T5

EXPERIMENTAL

Small Lottery reward

Behavioral: Financial incentive through lotteries

Control group

NO INTERVENTION

Treatment group T1

EXPERIMENTAL

High Lottery reward

Behavioral: Financial incentive through lotteries

Interventions

Introduction of financial incentives in the form of a lottery to remain/become STI-negative, which we believe is both replicable and relatively easy to scale-up.

Also known as: Behavioral
Treatment group T1Treatment group: T5

Eligibility Criteria

Age18 Years - 45 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Clinical diagnosis of HIV/AIDS ans STI

You may not qualify if:

  • none

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Lucia Corno

London, United Kingdom

Location

Related Publications (1)

  • Bjorkman Nyqvist M, Corno L, de Walque D, Svensson J. HIV, risk, and time preferences: Evidence from a general population sample in Lesotho. Health Econ. 2022 May;31(5):904-911. doi: 10.1002/hec.4476. Epub 2022 Feb 11.

MeSH Terms

Conditions

Sexually Transmitted DiseasesAcquired Immunodeficiency Syndrome

Condition Hierarchy (Ancestors)

Communicable DiseasesInfectionsGenital DiseasesUrogenital DiseasesDisease AttributesPathologic ProcessesPathological Conditions, Signs and SymptomsHIV InfectionsBlood-Borne InfectionsSexually Transmitted Diseases, ViralLentivirus InfectionsRetroviridae InfectionsRNA Virus InfectionsVirus DiseasesSlow Virus DiseasesImmunologic Deficiency SyndromesImmune System Diseases

Study Officials

  • Damien de Walque, Phd

    World Bank

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
early phase 1
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 19, 2010

First Posted

May 2, 2012

Study Start

February 1, 2010

Primary Completion

February 1, 2010

Study Completion

June 1, 2012

Last Updated

May 2, 2012

Record last verified: 2012-05

Locations