NCT01586130|Completed
Assessing the Impact of Isokinetic Muscular Strengthening in Eccentric Mode in the Medical Treatment of Knee Osteoarthritis
ISOGO
Loading search results
ISOGO
Sponsor study identifier
interventional
40
1 country
1
Study Start
February 2012
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
August 2014
Actual (reported)Study Completion
December 31, 2018
Actual (reported)Knee osteoarthritis (O.A. from now on) is associated to muscular weakness of inferior limbs, especially the quadriceps; leading to disease progression. Advantages of muscular strength training for the treatment of this kind of O.A. is now well established. In this therapeutic field, isokinetic exercises seem to have a better efficiency than other, more frequently used, kinds of exercises such as isometric or isotonic exercises. Functional impairment caused by knee O.A. is mainly affecting walking. Walking induces muscles to work in eccentric mode. The hypothesis of this study is that muscular strengthening using isokinetic exercises in eccentric mode would have a more important benefit than isokinetic exercises in concentric mode. Such an hypothesis, if verified, could lead to a better management of rehabilitative knee exercises in the treatment of knee O.A.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 31, 2018
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
February 2012
Date type not reportedThis date has not been verified as actual or estimated.
February 16, 2012
Actual (reported)April 26, 2012
Actual (reported)August 2014
Actual (reported)December 31, 2018
Actual (reported)Difference of peak torque of quadriceps
6 months after treatment start
Walk speed (50 meters and 200 meters)
at day 1, 6 weeks, and 6 months :
Knee pain (via analogic visual scales)
at day 1, 6 weeks, and 6 months
Posture parameters (posturography)
at day 1, 6 weeks, and 6 months
WOMAC Scores
at day 1, 6 weeks, and 6 months
Knee perimeter
at day 1, 6 weeks, and 6 months
In this therapeutic field, isokinetic exercises seem to have a better efficiency than other, more frequently used, kinds of exercises such as isometric or isotonic exercises.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
CHU Clermont-Ferrand
Clermont-Ferrand, 63003, France
Coudeyre E, Pereira B, Lechauve JB, Girold S, Richard R, Dobija L, Lanhers C. Eccentric Muscle Strengthening Using Maximal Contractions Is Deleterious in Knee Osteoarthritis: A Randomized Clinical Trial. J Clin Med. 2024 Jun 4;13(11):3318. doi: 10.3390/jcm13113318.
Jegu AG, Pereira B, Andant N, Coudeyre E. Effect of eccentric isokinetic strengthening in the rehabilitation of patients with knee osteoarthritis: Isogo, a randomized trial. Trials. 2014 Apr 2;15:106. doi: 10.1186/1745-6215-15-106.
Emmanuel COUDEYRE
University Hospital, Clermont-Ferrand
40 participants (actual enrollment reported by the registry).
First Submitted
February 16, 2012
First Posted
April 26, 2012
Study Start
February 2012
Date type not reportedThis date has not been verified as actual or estimated.
Contact the study team to confirm eligibility.
Primary Completion
August 2014
Actual (reported)Study Completion
December 31, 2018
Actual (reported)Last Updated
April 21, 2026
Record last verified: 2026-04
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.
Source retrieved: