Obstructive Sleep Apnea in Pulmonary Embolism

NCT01580085 | Completed

• 1 other identifier: gantep gogus 1
• Study Type: observational
• Target: 75
• Locations: 1 country
• Sites: 1

Brief Summary

Obstructive sleep apnea (OSA) is a clinical syndrome characterized by repetitive closure of the airway and frequent awakenings during sleep. Repeated episodes of hypoxia, decrease in intrathoracic pressure, increased venous return and venous stasis, damage to vascular wall may ensue. An increased tendency for coagulation has also been reported in OSA. Venous stasis, vascular endothelial activation and hypercoagulability are also known risk factors for thromboembolism. All of these pathophysiologic changes in OSA may predispose patients for the development of pulmonary embolism (PE) however there is limited data about role of thromboembolic events in OSA.

Conditions

Pulmonary Thromboembolism; Obstructive Sleep Apnea

Keywords

Sleep disordered breathing; gender; hypercoagulability

Study Arms (2)

Pulmonary embolism

Patients who were diagnosed with pulmonary embolism

Other: polysomnography

control group

age and sex matched adults with osa and no thromboembolism

Other: polysomnography

Interventions

polysomnography OTHER

full night supervised laboratory polysomnography

Also known as: PSG

Pulmonary embolism; control group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All subjects admitted to Department of Pulmonary Medicine of Gaziantep University who were diagnosed to have PE were included in the study group. Control group consisted of age and sex matched subjects without a clinic consistent with PE referred to the Sleep Clinic. PE was diagnosed when one or more of the following was present: compatible physical examination findings and multislice CT angiography or presence of deep venous thrombus (DVT) in addition to high risk with Wells criteria \[5\]. Subjects with any restrictive/obstructive lung pathology or younger than 18 years old were excluded.

You may qualify if:

• All consecutive patients diagnosed with pulmonary embolism

You may not qualify if:

• less than 18 years of age
• any restrictive or obstructive lung disease

Sponsors & Collaborators

• University of Gaziantep: lead

Study Sites (1)

University of Gaziantep Hospital

Gaziantep, 27310, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Pulmonary Embolism; Sleep Apnea, Obstructive; Sleep Apnea Syndromes; Coitus; Thrombophilia

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Embolism; Embolism and Thrombosis; Vascular Diseases; Cardiovascular Diseases; Apnea; Respiration Disorders; Sleep Disorders, Intrinsic; Dyssomnias; Sleep Wake Disorders; Nervous System Diseases; Sexual Behavior; Behavior; Hematologic Diseases; Hemic and Lymphatic Diseases

Study Officials

• Meral Uyar, Assist Prof

  University of Gaziantep

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Asisstant Professor

Study Record Dates

• First Submitted: April 16, 2012
• First Posted: April 18, 2012
• Study Start: November 1, 2009
• Primary Completion: December 1, 2010
• Study Completion: December 1, 2010
• Last Updated: April 18, 2012

Record last verified: 2012-04

Locations

TU (1)