Citalopram vs Clomipramine vs Placebo in Recurrent Depression
1 other identifier
interventional
59
0 countries
N/A
Brief Summary
citalopram and clomipramine are better than placebo in preventing new episodes of depression in patients with recurrent depression
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable depression
Started Oct 1997
Longer than P75 for not_applicable depression
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 1997
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2007
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2007
CompletedFirst Submitted
Initial submission to the registry
April 10, 2012
CompletedFirst Posted
Study publicly available on registry
April 11, 2012
CompletedApril 11, 2012
April 1, 2012
9.9 years
April 10, 2012
April 10, 2012
Conditions
Outcome Measures
Primary Outcomes (1)
2 Hamilton Depression Rating Scale scores of at least 16 with one weeks interval or initiation of another antidepressant treatment
2 years of follow-up
Secondary Outcomes (1)
Study termination due to adverse event or non-compliance
2 years of follow-up
Study Arms (3)
citalopram
EXPERIMENTALcitalopram
clomipramnine
ACTIVE COMPARATORclomipramine
placebo
PLACEBO COMPARATORplacebo
Interventions
Eligibility Criteria
You may qualify if:
- Patients with recurrent depression
- Sustained response achieved (3 consecutive monthly ratings at the HDS below 13)after a treatment requiring index episode
You may not qualify if:
- Contraindications to study medications
- Pregnancy
- Substance abuse
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Aarhuslead
- Danish University Antidepressant Groupcollaborator
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
April 10, 2012
First Posted
April 11, 2012
Study Start
October 1, 1997
Primary Completion
September 1, 2007
Study Completion
September 1, 2007
Last Updated
April 11, 2012
Record last verified: 2012-04