NCT01569594

Brief Summary

Assess device performance data from subjects undergoing patch angioplasty of the carotid artery following carotid endarterectomy using the CorMatrix ECM for Carotid Repair.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
230

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Apr 2012

Longer than P75 for all trials

Geographic Reach
1 country

6 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 30, 2012

Completed
2 days until next milestone

Study Start

First participant enrolled

April 1, 2012

Completed
2 days until next milestone

First Posted

Study publicly available on registry

April 3, 2012

Completed
4.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2016

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2016

Completed
3.2 years until next milestone

Results Posted

Study results publicly available

February 24, 2020

Completed
Last Updated

July 21, 2023

Status Verified

July 1, 2023

Enrollment Period

4.8 years

First QC Date

March 30, 2012

Results QC Date

January 31, 2020

Last Update Submit

July 19, 2023

Conditions

Outcome Measures

Primary Outcomes (1)

  • Carotid Procedure and Device Related Adverse Events to Determine Device Performance

    2 years

Study Arms (1)

Carotid Endarterectomy Subjects

Subjects undergoing patch angioplasty of the carotid artery following carotid endarterectomy using the CorMatrix ECM for Carotid Repair

Device: CorMatrix ECM for Carotid Repair

Interventions

Subjects must be undergoing carotid endarterectomy with patch angioplasty closure

Carotid Endarterectomy Subjects

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Up to 230 subjects may be enrolled from up to ten U.S. clinical sites

You may qualify if:

  • Subjects must be undergoing carotid endarterectomy with patch angioplasty closure.
  • Subject's operative surgeon intends to use CorMatrix ECM as the patch material for closure of the carotid artery per its FDA cleared Indications for Use.
  • The subject must possess the ability to provide written Informed Consent.
  • The subject must express an understanding and willingness to fulfill all of the expected requirements of this clinical protocol.

You may not qualify if:

  • Subjects with a known sensitivity to porcine material.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (6)

Cardio-Thoracic Surgeons, P.C. Trinity

Birmingham, Alabama, 35243, United States

Location

Vascular Surgical Associates P.C.

Marietta, Georgia, 30060, United States

Location

Cardiac Surgery Associates

Indianapolis, Indiana, 46237, United States

Location

St Luke's Hospital

Kansas City, Missouri, 64111, United States

Location

Cardiovascular Surgery Clinic, PLLC

Memphis, Tennessee, 38120, United States

Location

UVA Heart and Vascular Center

Charlottesville, Virginia, 22908, United States

Location

MeSH Terms

Conditions

Carotid Stenosis

Condition Hierarchy (Ancestors)

Carotid Artery DiseasesCerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesArterial Occlusive DiseasesVascular DiseasesCardiovascular Diseases

Results Point of Contact

Title
Clinical Director
Organization
Aziyo Biolgics, Inc.

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 30, 2012

First Posted

April 3, 2012

Study Start

April 1, 2012

Primary Completion

December 31, 2016

Study Completion

December 31, 2016

Last Updated

July 21, 2023

Results First Posted

February 24, 2020

Record last verified: 2023-07

Locations