NCT01565434

Brief Summary

Main objective: investigate whether a functional polymorphism of CR1 (length, number of binding sites in C4b C3b, erythrocyte density, rate of soluble CR1 ...) so determined genetic or acquired, is a susceptibility factor for the disease Alzheimer's.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
200

participants targeted

Target at P75+ for not_applicable alzheimer-disease

Timeline
Completed

Started Feb 2012

Typical duration for not_applicable alzheimer-disease

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 1, 2012

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

March 26, 2012

Completed
2 days until next milestone

First Posted

Study publicly available on registry

March 28, 2012

Completed
3 years until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2015

Completed
Last Updated

January 21, 2026

Status Verified

March 1, 2012

First QC Date

March 26, 2012

Last Update Submit

January 19, 2026

Conditions

Alzheimer Disease

Interventions

CR1 impactOTHER

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • caucasians people with a Alzheimer dementia defined on DSMIV criteria for patients and without Alzheimer disease for control subjects

You may not qualify if:

  • diseases modifying CR1 physiology

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

CHU de REIMS

Reims, 51092, France

Location

Related Publications (2)

  • Mahmoudi R, Kisserli A, Novella JL, Donvito B, Drame M, Reveil B, Duret V, Jolly D, Pham BN, Cohen JH. Alzheimer's disease is associated with low density of the long CR1 isoform. Neurobiol Aging. 2015 Apr;36(4):1766.e5-1766.e12. doi: 10.1016/j.neurobiolaging.2015.01.006. Epub 2015 Jan 9.

    PMID: 25666996BACKGROUND

  • Mahmoudi R, Feldman S, Kisserli A, Duret V, Tabary T, Bertholon LA, Badr S, Nonnonhou V, Cesar A, Neuraz A, Novella JL, Cohen JHM. Inherited and Acquired Decrease in Complement Receptor 1 (CR1) Density on Red Blood Cells Associated with High Levels of Soluble CR1 in Alzheimer's Disease. Int J Mol Sci. 2018 Jul 25;19(8):2175. doi: 10.3390/ijms19082175.

    PMID: 30044434RESULT

MeSH Terms

Conditions

Alzheimer Disease

Condition Hierarchy (Ancestors)

DementiaBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesTauopathiesNeurodegenerative DiseasesNeurocognitive DisordersMental Disorders

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Purpose
SCREENING
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 26, 2012

First Posted

March 28, 2012

Study Start

February 1, 2012

Study Completion

April 1, 2015

Last Updated

January 21, 2026

Record last verified: 2012-03

Locations

FR(1)