Magnesium is Associated With QoL in COPD: A Cross-sectional Study

NCT01564953 | Completed Results

• 1 other identifier: M-20110280
• Study Type: observational
• Target: 143
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study was to investigate the associations between serum concentrations of vitamin D, Magnesium and Calcium in Chronic obstructive pulmonary disease patients and the potential impact of these parameters on lung function and quality of life.

Conditions

Chronic Obstructive Pulmonary Disease (COPD)

Keywords

vitamin D; calcium; magnesium; COPD; QoL

Outcome Measures

Primary Outcomes (1)

• Serum Vitamin D

  vitamin D measured by p-25-hydroxy-vitamin D2 + D3, in mmol/L

  one year

Secondary Outcomes (4)

• Lung Function Test

  one year

• Serum Magnesium

  One year

• Serum Calcium

  One year

• Quality of Life

  One year

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Outpatients from the Department Of Resoiratory Diseases, Aarhus University Hospital

You may qualify if:

• COPD-patients
• Unchanged medical treatment for COPD for the last 4 weeks
• Outpatients
• adults over 40 years

You may not qualify if:

• COPD exacerbation, which resulted in hospitalization and/or modification of medical treatment within 4 weeks
• Patients with other lung diseases, such as active tuberculosis, lung cancer, sarcoidosis and pulmonary fibrosis
• diseases affecting vitamin D and/or calcium and/or magnesium distribution
• Previous lung resection
• Treatment with systemic steroids
• Known addiction problems with alcohol and/or drugs

Sponsors & Collaborators

• University of Aarhus: lead
• Aarhus University Hospital: collaborator

Study Sites (1)

Aarhus University Hospital

Aarhus, 8000, Denmark

Location

Related Publications (1)

• Hashim Ali Hussein S, Nielsen LP, Konow Bogebjerg Dolberg M, Dahl R. Serum magnesium and not vitamin D is associated with better QoL in COPD: A cross-sectional study. Respir Med. 2015 Jun;109(6):727-33. doi: 10.1016/j.rmed.2015.03.005. Epub 2015 Mar 27.

  PMID: 25892292 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

Blood samples: p-creatinine p-potassium p-sodium p-albumine p-phosphate p-magnesium p-calcium-ion p-parathyrine p-25-hydroxy-vitamin D2 + D3

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Limitations and Caveats

The cross-sectional design. Some data (e.g. number of exacerbations past one year and smoking history) were self-reported and therefore, a risk of recall-bias cannot be excluded.

Results Point of Contact

• Title: Dr. Sarah Hashim Ali Hussein
• Organization: Aarhus University Hospital

sarsuri@hotmail.com

0045 42660308

Study Officials

• Ronald Dahl, Professor

  Allergy Centre, Odense University Hospital

  STUDY DIRECTOR

• Sarah HA Hussein, MD

  Department of Respiratory Diseases, Aarhus University Hospital

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: observational
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 26, 2012
• First Posted: March 28, 2012
• Study Start: February 1, 2012
• Primary Completion: October 1, 2012
• Study Completion: January 1, 2013
• Last Updated: March 6, 2017
• Results First Posted: March 6, 2017

Record last verified: 2013-01

Data Sharing

• IPD Sharing: Will share

Locations

DK (1)