Patient Retrospective Outcomes (PRO)
PRO
1 other identifier
observational
15,000
14 countries
144
Brief Summary
This study will evaluate de-identified (anonymous) data in subject medical charts to review the clinical outcomes of various treatment approaches in the treatment of chronic pain.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Apr 2012
Longer than P75 for all trials
144 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 5, 2012
CompletedFirst Posted
Study publicly available on registry
March 12, 2012
CompletedStudy Start
First participant enrolled
April 3, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2030
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 1, 2030
June 12, 2026
June 1, 2026
18.7 years
March 5, 2012
June 10, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Responder rate
Responder rate for pain relief through study completion.
Through study completion, approximately two years
Study Arms (2)
Patients eligible for SCS, RF or other treatment approaches
Patients who have previously been implanted with, or are eligible for implantation with a spinal cord stimulation system or various other treatment approaches such as RF, IDS, etc.
Patients Eligible for treatment options with prior treatment
Patients who have previously been implanted with a spinal cord stimulation system or other various treatments, and have thereafter received a different form of chronic pain treatment such as a different SCS system, RF, IDS etc.
Interventions
Spinal cord stimulation, RF, IDS etc.
Spinal cord stimulation, RF, IDS etc
Eligibility Criteria
Subjects who have previously been implanted with, or who are candidates for implantation with a spinal cord stimulation system or other various treatment approaches, such as radio frequency ablation or indirect decompression system (IDS).
You may qualify if:
- Previously treated with or eligible for use with Boston Scientific Systems
- years of age or older at the start of Baseline
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (144)
Lakeside Spine & Pain
Lake Havasu City, Arizona, 86403, United States
Hope Research Institute
Phoenix, Arizona, 85018, United States
Kern Neuroscience Institute
Bakersfield, California, 93306, United States
Pain Consultants of San Diego
Chula Vista, California, 91914, United States
Pain Medicine Associates, Inc.
Fountain Valley, California, 92708, United States
UCSD Medical Center - Jacobs Medical Center
La Jolla, California, 92037, United States
California Orthopedics & Spine
Larkspur, California, 94939, United States
MarinHealth Spine Institute
Larkspur, California, 94939, United States
Loma Linda University Medical Center
Loma Linda, California, 92354, United States
Newport Beach Headache and Pain
Newport Beach, California, 92660, United States
Vitamed Research
Rancho Mirage, California, 92270, United States
Pacific Pain Management, Inc.
Ventura, California, 93003, United States
IPM Medical Group Inc.
Walnut Creek, California, 94598, United States
Barolat Neuroscience
Denver, Colorado, 80218, United States
Advanced Diagnostic Pain Treatment Centers
New Haven, Connecticut, 06511, United States
Orlando Health Neuroscience Institute
Clermont, Florida, 34711, United States
Florida Spine Specialists
Fort Lauderdale, Florida, 33308, United States
Louis J. Raso, MD, PA
Jupiter, Florida, 33477, United States
Florida Pain Institute
Merritt Island, Florida, 32953, United States
Advanced Interventional Pain Management and Research Clinic, Inc.
Miami Gardens, Florida, 33169, United States
Florida Pain Clinic
Ocala, Florida, 34471, United States
Orthomicrospine
Pensacola, Florida, 32503, United States
HCA Florida West Orthopedic Specialists
Pensacola, Florida, 32514, United States
West Florida Orthopedics and Spine Surgery
Pensacola, Florida, 32514, United States
Interventional Spine and Pain Institute
Vero Beach, Florida, 32960, United States
Orthopedic Research Foundation
Savannah, Georgia, 31405, United States
Centurion Spine and Pain
Waycross, Georgia, 31522, United States
Tripler Army Medical Center
Honolulu, Hawaii, 96859, United States
Pain and Spine Specialists of Idaho
Idaho Falls, Idaho, 83404, United States
North Idaho Day Surgery
Post Falls, Idaho, 83854, United States
Northwestern Memorial Hospital
Chicago, Illinois, 60611, United States
Summit Research Institute
Fort Wayne, Indiana, 46825, United States
Comprehensive Pain and Spine Specialists
Muncie, Indiana, 47304, United States
Henry Community Health
New Castle, Indiana, 47362, United States
Precision Spine Care
Overland Park, Kansas, 66211, United States
Willis-Knighton River Cities Clinical Research Center
Shreveport, Louisiana, 71105, United States
Pain and Spine Specialist of Maryland
Mount Airy, Maryland, 21771, United States
Michigan Orthopedic Center
Lansing, Michigan, 48910, United States
Multidisciplinary Pain Management Services
Okemos, Michigan, 48864, United States
Forest Health Medical Center
Ypsilanti, Michigan, 48198, United States
Twin Cities Pain Clinic & Surgery Center
Edina, Minnesota, 55439, United States
NeuroSpecs-Gulfport Performance Spine
Gulfport, Mississippi, 39503, United States
Comprehensive Pain & Rehabilitation
Pascagoula, Mississippi, 39581, United States
Saint Louis Pain Consultants
Chesterfield, Missouri, 63017, United States
Mercy Medical Research Institute
Springfield, Missouri, 65804, United States
Albany Medical Center
Albany, New York, 12208, United States
Jeffrey M. Epstein, M.D. PC
Babylon, New York, 11702, United States
Montefiore Medical Center
The Bronx, New York, 10461, United States
Spine and Skeletal Pain Medicine
Utica, New York, 13502, United States
Integrative Pain and Wellness Associates
Williamsville, New York, 14221, United States
Vidant Roanoke - Chowan Hospital Pain Center
Ahoskie, North Carolina, 27910, United States
Carolinas Research Institute, PLLC
Huntersville, North Carolina, 28078, United States
Crystal Coast Pain Management
New Bern, North Carolina, 28560, United States
Piedmont Interventional Pain Care
Salisbury, North Carolina, 28147, United States
The Center for Clinical Research, LLC
Winston-Salem, North Carolina, 27103, United States
Interventional Pain and Spine
Cincinnati, Ohio, 45202, United States
University Hospitals of Cleveland
Cleveland, Ohio, 44106, United States
Orthopaedic and Spine Center
Dublin, Ohio, 43016, United States
Cincinnati Comprehensive Pain Center
Fairfield, Ohio, 45014, United States
Western Reserve Spine and Pain Institute
Kent, Ohio, 44240, United States
Interventional Pain Consultants
Toledo, Ohio, 43623, United States
Toledo Clinic
Toledo, Ohio, 43623, United States
University of Toledo Medical Center
Toledo, Ohio, 43623, United States
Pacific Sports and Spine, LLC
Eugene, Oregon, 97401, United States
Pain Specialists of Southern Oregon
Medford, Oregon, 97504, United States
Quave Clinic
Medford, Oregon, 97504, United States
Southern Oregon Orthopedics
Medford, Oregon, 97504, United States
Summit Spine
Portland, Oregon, 97225, United States
Geisinger Medical Center
Danville, Pennsylvania, 17822, United States
Florence Neurosurgery and Spine
Florence, South Carolina, 29506, United States
PCPMG Clinical Research Unit, LLC
Greenville, South Carolina, 29601, United States
Interventional Spine and Pain Center
Manchester, Tennessee, 37355, United States
Comprehensive Pain & Neurology Center
Murfreesboro, Tennessee, 37128, United States
Pain Center Physicians
Austin, Texas, 78704, United States
Balcones Pain Consultants
Austin, Texas, 78750, United States
KSF Orthopaedics
Houston, Texas, 77090, United States
Central Texas Pain Institute
Killeen, Texas, 76542, United States
Advanced Spine Pain Solutions
Laredo, Texas, 78041, United States
Spine Team Texas
Southlake, Texas, 76092, United States
Space City Pain Specialists
Webster, Texas, 77598, United States
University of Utah Orthopaedic Center
Salt Lake City, Utah, 84108, United States
Carilion Roanoke Memorial Hospital
Roanoke, Virginia, 24014, United States
EvergreenHealth Pain Care
Kirkland, Washington, 98034, United States
Mind Your Body Institute
Seattle, Washington, 98115, United States
Northwest Pain Care
Spokane, Washington, 99201, United States
West Virginia University Hospitals
Morgantown, West Virginia, 26506, United States
Interventional Pain Specialists of Wisconsin
Rice Lake, Wisconsin, 54868, United States
Berwick Pain Management
Berwick, Australia
Hunter Pain Clinic
Broadmeadow, Australia
Monash Clinical Research
Caulfield South, Australia
Green Lizard Science
Claremont, Australia
Sydney Spine and Pain Pty Ltd
Hurstville, Australia
Sunshine Coast Clinical Research
Noosa, Australia
Womens Health and Research Institute of Australia
Sydney, Australia
Pain Medicine of South Australia
Wayville, Australia
Clinique Saint-Pierre Ottignies
Ottignies, Belgium
Polyclinique du Parc
Caen, France
Clinique de la Sauvegarde
Lyon, France
Hopital Prive du Confluent SAS
Nantes, France
Fondation Ophtalmologique Adolphe de Rothschild
Paris, France
CHU La Miletrie
Poitiers, France
CHU de Nantes-Hopital Laennec
Saint-Herblain, France
Hopital Foch
Suresnes, France
Inter Neuro
Berlin, Germany
Uniklinik Köln
Cologne, Germany
Universitaetsklinikum Dusseldorf
Düsseldorf, Germany
St. Marien-Hospital Hamm
Hamm, Germany
University Berlin, Charite Virchow Standort, Wedding
Wedding, Germany
Pres. Osp. Civile Santi Antonio e Biagio
Alessandria, Italy
Az. Osp. Monaldi
Naples, Italy
AUSL della Romagna
Ravenna, Italy
Ospedale San Giuliano
Rionero in Vulture, Italy
Ospedale S. Giovanni Addolorata
Rome, 30326, Italy
Policlinico Universitario Agostino Gemelli
Rome, Italy
Azienda Ospedaliera Universitaria Integrata di Verona
Verona, Italy
Alrijne Ziekenhuis Leiderdorp
Leiderdorp, Netherlands
Ziekenhuis Rijnstate
Velp, Netherlands
CHU Sao Joao
Porto, Portugal
Ponce Interventional Pain Center
Ponce, 716, Puerto Rico
Hospital De Bellvitge
Barcelona, Spain
H. Puerta Del Mar
Cadiz, Spain
Complejo Hospitalario Universitario de Cartagena
Cartagena, Spain
Hospital Universitario Doctor Jose Molina Orosa
Las Palmas, Spain
Hospital San Pedro
Logroño, Spain
Fundacion Jimenez Diaz
Madrid, Spain
Hospital Clinico San Carlos
Madrid, Spain
Hospital La Paz
Madrid, Spain
Hospital Universitario Quiron Madrid
Madrid, Spain
Hospital Puerta de Hierro
Majadahonda, Spain
Complexo Hospitalario Universitario de Ourense (CHUO)
Ourense, Spain
Hospital Virgen Del Rocio
Seville, Spain
H. Clinico Universitario
Valencia, Spain
Hospital de la Ribera
Valencia, Spain
Hospital Universitario La Fe
Valencia, Spain
Sahlgrenska University Hospital
Gothenburg, Sweden
La Tour Hospital
Meyrin, Switzerland
Ospedale Regionale di Lugano
Viganello, Switzerland
Izmir Bakircay Üniversitesi
Izmir, Turkey (Türkiye)
Basildon and Thurrock University Hospitals NHS
Basildon, United Kingdom
Southmead Hospital Bristol
Bristol, United Kingdom
Royal Devon & Exeter Hospital
Exeter, United Kingdom
The General Infirmary
Leeds, United Kingdom
St. Bartholomews Hospital
London, United Kingdom
James Cook University Hospital
Middlesbrough, United Kingdom
Related Publications (2)
Ferro R, North J, Kranenburg A, Pyles S, Dorenkamp C, Poston J, Schneider J, Auten K, Goldberg E. Automated Neural Dosing for Fast-Acting Subperception Therapy: Sustained Spinal Cord Stimulation Outcomes from a Multicenter Study. Pain Ther. 2025 Aug;14(4):1417-1429. doi: 10.1007/s40122-025-00758-y. Epub 2025 Jul 3.
PMID: 40603812DERIVEDMetzger C, Hammond B, Ferro R, North J, Pyles S, Kranenburg A, Washabaugh E, Goldberg E. Two-year outcomes using fast-acting sub-perception therapy for spinal cord stimulation: results of a real-world multicenter study in the United States. Expert Rev Med Devices. 2025 Jan-Feb;22(2):155-164. doi: 10.1080/17434440.2025.2453554. Epub 2025 Jan 16.
PMID: 39819320DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Natalie Bloom Lyons
Boston Scientific Neuromodulation Corporation
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
March 5, 2012
First Posted
March 12, 2012
Study Start
April 3, 2012
Primary Completion (Estimated)
December 1, 2030
Study Completion (Estimated)
December 1, 2030
Last Updated
June 12, 2026
Record last verified: 2026-06